Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will join our Drug Substance Technologies
- Synthetics (DSTS) group at our Thousand Oaks campus. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen’s exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late‑stage development.

In this dynamic role, the individual will be responsible for developing innovative solutions to support chemical and bio‑conjugation process development of our hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The role includes providing technical expertise and translating developed processes toward manufacturing and commercialization. The successful candidate will be a highly motivated and team‑oriented individual with a strong background in organic chemistry and/or bioconjugation chemistry with a proven track record of scientific innovation and achievement.

Key Responsibilities:

• Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to invent synthetic routes and develop safe, robust, sustainable and cost‑effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
• Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross‑functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugation, antibody drug conjugate, oligonucleotide, peptide, and process chemistry and manufacturing
• Work independently in advancing projects and studies within required deadlines.

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is an individual with these qualifications.

• Doctorate degree PhD OR PharmD OR MD [and relevant post‑doc where applicable]
• OR
• Master’s degree and 3 years of Scientific experience
• OR
• Bachelor’s degree and 5 years of Scientific experience