Process Development Senior Principal Scientist Bioconjugates

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnesses drives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Lets do this. Lets change the world. In this vital role you will join Amgens DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

Amgen is currently seeking a talented Senior Principal Scientist who will lead a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes for bioconjugates, including antibody drug conjugates (ADCs), drive technology innovation, provide technical expertise, and develop and mentor staff within the organization. The successful candidate for this role will be a people-centered leader with deep expertise in bioconjugation process development and industrialization of bioconjugation manufacturing processes with a proven track record of scientific innovation and leadership within the pharmaceutical industry.

The role will be located atour Thousand Oaks, California campus.

• Lead a multidisciplinary project team in the development of sustainable and cost-effective processes for bioconjugate manufacturing at all stages of clinical development
• Drive bioconjugation technology innovation
• Support cGMP manufacturing and technology transfer to GMP production facilities
• Develop strategies to ensure process performance through process understanding, modeling and characterization
• Guide successful completion of project deliverables and ensure timelines are met
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugation manufacturing
• Coach and provide career and scientific / technical advice to colleagues within the organization

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of Scientific experience
  OR
• Masters degree and 6 years of Scientific experience
  OR
• Bachelors degree and 8 years of Scientific experience

• Doctoral degree and 5+ years in the pharmaceutical industry with expertise in bioconjugate process development, preferably in Antibody Drug Conjugates (ADCs) with HPAPI linker-payload synthesis experience
• GMP manufacturing and technology transfer to CMOs
• Demonstrated functional representation on a CMC or PDT team
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
• Proven track record of publications, patents and presentations

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your…