Senior Scientist

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while advancing your career.

The Department of Inflammation Research seeks a dedicated, driven, and independent Principal Scientist (manager) to join the In Vivo Pharmacology (IVP) group. You will design and execute experiments exploring and understanding the pharmacology of drug targets; generate, communicate pharmacology and preclinical data to support research progression; and provide technical expertise to therapeutic area scientists. This role may involve managing one report, contributing to project teams, and collaborating across multiple Amgen sites.

• A driven, proactive, independent, and enthusiastic scientist who wants to contribute to cutting‑edge science and serve patients in a highly productive team environment.
• Strong understanding of immunology and inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Significant hands‑on expertise in animal (mouse and rat) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) preferred.
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Preferred experience with colitis (DSS, CD45RB
  hi T cell transfer, IL‑10 KO), lupus (NZB/W, MRL‑lpr, Imiquimod), arthritis (CIA, CAIA), GvHD models; experience in HS, PBC a plus.
• Hands‑on experience in cellular, biochemical, histological, and molecular biology assay techniques (e.g., ELISA, MSD, quantitative RT‑PCR, BCA protein measurements) preferred. Hands‑on experience with multicolor flow cytometry including spectral flow approaches and immune cell populations is essential.
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint, and Word.
• Attention to detail, excellent organizational and communication skills, accurate & timely record‑keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in pharmacology and in vivo models of inflammation/immunology.
• Ability to work in a flexible, team‑oriented environment.

• Doctorate degree OR
• Masters degree and 2 years of drug discovery experience OR
• Bachelors degree and 4 years of drug discovery experience

• PhD degree and post‑doctoral training (or drug discovery experience) in the fields of immunology, inflammation, autoimmune disease, or related disciplines; 3‑5 years of management experience in industry or academia.
• Experience working on project teams leading in vivo contributions.

As we work to develop treatments that take care of others, we also care for our teammates, professional and personal growth and well‑being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted; actual salary will vary based on several factors, including but not limited to, relevant skills, experience, and qualifications.

• Comprehensive employee benefits package, including a retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program.
• Sto…