Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at our Thousand Oaks campus. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late‑stage development.

In this dynamic role, the individual will be responsible for developing innovative solutions to support chemical and bio‑conjugation process development of our hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The role includes providing technical expertise and translating developed processes toward manufacturing and commercialization. The successful candidate will be a highly motivated and team‑oriented individual with a strong background in organic chemistry and/or bioconjugation chemistry with a proven track record of scientific innovation and achievement.

Key Responsibilities:

• Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to invent synthetic routes and develop safe, robust, sustainable and cost‑effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
• Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross‑functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugation, antibody drug conjugate, oligonucleotide, peptide, and process chemistry and manufacturing
• Work independently in advancing projects and studies within required deadlines

Basic Qualifications:

• Doctorate degree PhD OR Pharm
  
  D OR MD [and relevant post‑doc where applicable]
• OR
• Master’s degree and 3 years of Scientific experience
• OR
• Bachelor’s degree and 5 years of Scientific experience

Preferred Qualifications:

• Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development
• Post‑doctoral experience in an academic laboratory or pharmaceutical/biotech industry
• Extensive hands‑on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bio‑conjugation techniques
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC‑MS), Ion‑Exchange (IEX), and Reversed Phase (RP)-HPLC
• Familiarity with laboratory automation, data analysis and visualization techniques and tools
• Track record of peer‑reviewed publications and research presentations
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• A research summary included with CV is strongly encouraged

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

• A comprehensive employee benefits package, including a…