Postdoctoral Fellow-Discovery Proteomics

** What you will do*
* Let's do this! Let's change the world.

The Post Doctoral Fellow at Amgen conducts research under the supervision of a mentor. They contribute to the design and execution of research projects, the analysis of data, and the preparation of scientific manuscripts.

** Position Overview*
* This postdoctoral project focuses on understanding how biochemical state, cellular context, and subcellular localization influence substrate recruitment to E3 ligases such as Cereblon (CRBN). The fellow will leverage cutting-edge in-cell proximity labeling technologies (Turbo

ID), quantitative proteomics, and cellular perturbation approaches to define mechanistically meaningful recruitment events relevant to molecular glue discovery.

The position is ideal for candidates with strong training in cell biology, molecular biology, or biochemistry, particularly in ubiquitin biology, targeted protein degradation, or E3 ligase biology, who are interested in applying proteomics approaches to mechanistic questions in targeted protein degradation.

Prior hands-on proteomics expertise is not required; however, familiarity with proteomics approaches and enthusiasm for learning advanced quantitative proteomics methodologies are highly desirable.

** Key Responsibilities*
* + Design and execute cellular and biochemical experiments to study molecular glue-mediated E3 ligase recruitment

+ Develop and apply proximity labeling and targeted perturbation strategies in engineered cellular systems

+ Investigate context-dependent recruitment mechanisms involving post-translational modifications, protein complexes, and subcellular localization

+ Collaborate closely with proteomics scientists to generate and interpret quantitative mass spectrometry datasets

+ Integrate biological and proteomic datasets to develop mechanistic models of induced proximity biology

+ Present findings and contribute to the preparation of scientific manuscripts, publications, and scientific communications.

** Basic Qualifications*
* + PhD completed prior to start date in Cell Biology, Molecular Biology, Biochemistry, Chemical Biology, Immunology, Cancer Biology, or related discipline

** Preferred Qualifications*
* + Strong background in cell and molecular biology with demonstrated experimental independence

+ Experience in ubiquitin biology, E3 ligases, targeted protein degradation, or induced proximity biology

+

Experience with mammalian cell culture, CRISPR engineering, protein interaction studies, or signaling biology

+ Familiarity with proteomics or mass spectrometry-based approaches

+ Strong publication record, including first-author publications in high-impact peer-reviewed journals

+ Strong communication and collaborative skills

** Scientific Environment*
* The fellow will join a highly collaborative environment at the intersection of proteomics, TPD biology, and translational drug discovery. The project leverages established high-throughput Turbo

ID proximity labeling workflows, advanced quantitative proteomics platforms, and close collaborations across discovery biology and proteomics teams.

This position offers outstanding opportunities for scientific growth in induced proximity biology, quantitative proteomics, and translational therapeutic discovery, with expected authorship on high-impact publications.

** Apply now and make a lasting impact with the Amgen team.*
* ***
* In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

** Final date to receive applications*
* Amgen does not have an Final date to receive applications for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

** Sponsorship*
* Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve…