Senior Scientist, In Vivo Pharmacology, Inflammation Research; Respiratory Focus

Senior Scientist, In Vivo Pharmacology, Inflammation Research (Respiratory Focus) What you will do

In this vital role you will lead highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs, managing interactions and presentation of results with project teams and collaborators.

• Lead and perform hands‑on in vivo work and run concurrent studies on mice (and possibly rats)
• Serve as manager with at least two direct reports (Scientists and Associate Scientists)
• Design experiments, oversee study execution, and ensure studies are completed on schedule
• Act as in vivo PTR on project teams: represent and communicate in vivo data to project teams and department
• Mentor, support, and manage direct reports performance, development, and supervision
• Maintain organization, attention to detail, and study preparation
• Participate in panels/seminars as part of interview/hiring and in broader scientific communication as needed
• Participate in weekend/evening dosing rotations when required.

The Senior Scientist we seek is a driven, pro‑active, independent, and enthusiastic scientist who wants to contribute to cutting‑edge science and serve patients in a highly productive team environment, with strong understanding of immunology and inflammation biology and principles.

• Doctorate degree (PhD)
• PharmD
• MD with experience in immunology
• Master’s degree and at least 3 years of related experience in immunology
• Bachelor’s degree and at least 5 years of related experience in immunology

• Willingness and curiosity to learn and explore new areas of research
• Significant experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t., i.d., s.c.), respiratory virus infection (PR8)
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC
• Significant hands‑on expertise in animal handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy)
• Significant experience with lung function measurements (Flexi Vent, Plethysmography), imaging (mCT), and inhaled drug delivery
• Hands‑on experience in cellular, biochemical, histological, and molecular biology assay techniques (e.g., ELISA, MSD, quantitative RT‑PCR, BCA protein measurements)
• Hands‑on experience with multicolor flow cytometry including spectral flow approaches; immune cell populations is essential
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint, and Word
• Attention to detail, excellent organizational and communication skills, accurate & timely record‑keeping and data analysis are essential
• Demonstrated track record of independent critical thinking and scientific achievement
• Demonstrated experience in pharmacology with application using in vivo models of inflammation/immunology
• Experience working on project teams leading in vivo contributions
• Experience managing an in vivo pharmacology team or direct reports (2 years)
• Ability to work in a flexible team‑oriented environment; weekend and evening work may be required

Us we offer a competitive benefits package and a supportive environment for professional growth and well‑being.

• Health and welfare plans for staff and eligible dependents, including dental and vision coverage, life and disability insurance, and flexible spending accounts
• Retirement and savings plans with generous company contributions
• Discretionary annual bonus program and potential long‑term equity incentives
• Award‑winning time‑off plans
• Flexible work models where possible

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process.