Scientist, In Vivo Pharmacology, Inflammation Research

Scientist, In Vivo Pharmacology, Inflammation Research Key Responsibilities

• Perform hands‑on in vivo work primarily mice, possibly rats and run concurrent studies
• Design experiments and execute studies, working alongside senior scientists and associate scientists
• Generate high‑quality experimental data and ensure studies are organized and prepared
• Supervise/coordinate associate scientists tasks/time as needed for study execution.
• Analyze and communicate results to project teams and the broader department
• Understand the biology of supported projects and contribute to project progression
• Participate in occasional weekend/evening dosing rotations as required.

Doctorate degree OR Master’s degree and 2 years of Immunology or related experience OR Bachelor’s degree and 4 years of Immunology or related experience.

• PhD degree and post‑doctoral training (or drug discovery experience) in the fields of Immunology, inflammation autoimmune disease, or related disciplines.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t., i.d., s.c.), respiratory virus infection (PR8) models preferred.
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC important.
• Significant Experience with lung function measurements (Flexi Vent, Plethysmography), imaging (mCT), and inhaled drug delivery preferred.
• Hands‑on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymph nodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).
• Hands‑on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi‑color flow cytometry, quantitative RT‑PCR) preferred.
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organizational and communication kills, accurate & timely recordkeeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in and understanding of pharmacology with application using in vivo models of inflammation/Immunology.
• Experience working on project teams leading in vivo contributions.
• Ability to work in a flexible team‑oriented environment. Weekend and evening work may be required.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process and to perform essential job functions.