Senior Scientist - Cardiometabolic Disorders

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Senior Scientist - Cardiometabolic Disorders*
* ** What you will do*
* Let's do this. Let's change the world. In this vital role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients.

The proposal and advancement of drug discovery programs will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies.

Critical thinking, ingenuity, the ability to independently design mechanistic studies and conduct  _reproducible in vivo_  and in vitro pharmacology studies with high technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical for this role.

You will initially work at the bench and/or vivarium conducting  _in vivo_  and/or in vitro preclinical studies with a focus on osteoporosis and metabolic disease. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research.

As part of the team, you will also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio.

Key Responsibilities:

+ Conceptualizing and proposing therapeutic targets for the treatment of bone disease and cardiometabolic disease

+ Designing and performing  _in vitro_  and/or  _in vivo_  experiments

+ Independently performing data analysis and interpreting results

+ Communicating scientific results through written and oral presentations

+ Collaborating with teams from other functions in the company to advance therapeutic candidates

+ Documenting studies in electronic laboratory notebooks and study reports.

+ Advising colleagues in areas of expertise

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications.

*
* Basic Qualifications:

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* Doctorate degree PhD

OR

PharmD

OR

MD [and relevant post-doc where applicable]

OR

Master's degree and 3 years of experience in bone metabolism and bone disease

OR

Bachelor's degree and 5 years of experience in bone metabolism and bone disease

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* Preferred Qualifications:

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* + PhD with postdoctoral experience in bone metabolism and metabolic disease (industry experience is strongly preferred)

+ Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients

+ Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data

+ Technical mastery of general molecular biology and cell-signaling analysis techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA

+ Basic knowledge of statistical methods applied…