Associate Scientist, In vivo Pharmacology, Inflammation

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will work in a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs.

• Perform hands‑on in vivo work primarily mice, possibly rats in the vivarium daily.
• Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down.
• Work side‑by‑side with Scientists/Senior Scientists to execute and help design experiments.
• Run concurrent studies, stay organized and detail‑oriented to meet study timelines.
• Participate in weekend/evening dosing rotations as needed.
• Support in vitro assays as required.
• Communicate results to immediate team and follow established protocols and safety procedures.
• Work in a flexible team‑oriented environment. Weekend and evening work may be required.

We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a driven, pro‑active, independent, and enthusiastic scientist who wants to contribute to cutting‑edge science and serve patients in a highly productive team environment with these qualifications.

Master’s degree and 1 year of Immunology or related experience

OR

Bachelor’s degree and 3 years of Immunology or related experience

• M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models.
  
  Experience with colitis (DSS, CD45RB
  hi T cell transfer, IL‑10 KO), lupus (NZB/W, MRL‑lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in Asthma, COPD, HS, PBC a plus.
• Hands‑on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymph nodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).
• Hands‑on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT‑PCR, BCA protein measurements) preferred. Hands‑on experience with multicolor flow cytometry including Spectral flow approaches and immune cell populations is essential.
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in…