Organic and Conjugation Chemist

Career Category

Scientific

Senior Associate – Organic and Conjugation Chemist

The Hybrid Modality Group at Amgen is seeking a highly motivated scientist in the field of Antibody Drug Conjugates (ADC) to join us in the state‑of‑the‑art research facility at the Amgen headquarters campus located in Thousand Oaks, CA. The qualified candidate will work at the interface of synthetic chemistry, biochemistry, and chemical biology, and apply their chemical synthesis skills in developing new antibody drug conjugates to support the advancement of drug discovery programs.

• Perform multistep organic synthesis of linker‑payload reagents under supervision
• Purify and characterize small molecules using techniques such as flash chromatography, HPLC, LC/MS, and NMR.
• Learn and perform bioconjugation of antibodies, peptides, and small molecule payloads and characterize conjugates using analytical techniques, such as HPLC, LC-MS, and SEC
• Document experimental plans and procedures in electronic lab notebooks while following appropriate SOPs.
• Generate, analyze and summarize scientific data and provide regular updates on project results
• Operate and maintain standard lab equipment

• Master’s Degree
• Bachelor’s Degree and 2+ years of relevant experience
• Associate’s degree and 4 years of relevant experience
• High school diploma / GED and 6 years of relevant experience

• Experienced in organic synthesis including executing and optimizing chemical reactions
• Basic understanding of purification and analytical methods
• Eagerness to learn chemical conjugation and characterization of ADC
• Demonstration of good lab practices, with particular attention to safety
• Strong written and verbal communication skills
• Ability to work comfortably within a dynamic team of scientists and engineers with diverse technical and cultural backgrounds

From competitive benefits to a collaborative culture, we support your professional and personal growth and well‑being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

77,025.30 USD –  USD

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.