Senior Scientist, In Vivo Pharmacology, Inflammation Research; Respiratory Focus

Join Amgen's mission of serving patients. If you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we have helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on Oncology, Inflammation, General Medicine and Rare Disease, we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases and obesity‑related conditions. As a member of the Amgen team, you will help make a lasting impact on the lives of patients as we research, manufacture and deliver innovative medicines.

In this vital role you will lead a highly dynamic in vivo pharmacology team, executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs. You will manage interactions and presentation of results with project teams and collaborators.

• Lead and perform hands‑on in vivo work and run concurrent studies in mice and possibly rats.
• Serve as manager with at least two direct reports (Scientist and Associate Scientists).
• Design experiments, oversee study execution, and ensure studies are completed on schedule.
• Act as in vivo PTR on project teams: represent and communicate in‑vivo data to project teams and department.
• Mentor, support and manage direct reports’ performance, development and supervision.
• Maintain organization, attention to detail and study preparation.
• Participate in panels/seminars as part of interview/hiring and in broader scientific communication as needed.
• Participate in weekend/evening dosing rotations when required.

The Senior Scientist we seek is a driven, proactive, independent and enthusiastic scientist who wants to contribute to cutting‑edge science and serve patients in a highly productive team environment. Strong understanding of immunology and inflammation biology and principles is required.

• Doctorate degree (PhD) OR PharmD OR MD with immunology experience.
• Master’s degree and 3 years of focused immunology or related experience.
• Bachelor’s degree and 5 years of focused immunology or related experience.

• Willingness and curiosity to learn and explore new areas of research.
• Significant experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t., i.d., s.c.), respiratory virus infection (PR8).
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC.
• Significant hands‑on expertise in animal handling and in‑vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy).
• Significant experience with lung function measurements (Flexi Vent, Plethysmography), imaging (mCT) and inhaled drug delivery.
• Hands‑on experience in cellular, biochemical, histological, and molecular biology assay techniques (ELISA, MSD, quantitative RT‑PCR, BCA).
• Hands‑on experience with multicolor flow cytometry including spectral flow approaches; immune cell population analysis is essential.
• Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organization and communication skills, accurate and timely record‑keeping and data analysis.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in and understanding of pharmacology with application using in vivo models of inflammation/immunology.
• Experience working on project teams leading in vivo contributions.
• Experience managing an in vivo pharmacology team or direct reports (≥2 years).
• Ability to work in a flexible, team‑oriented environment. Weekend and evening work may be required.

Amgen supports professional and personal growth with a competitive benefits package and collaborative culture. We offer a total rewards plan that may…