Senior RNA Chemist RNA Therapeutics

Senior RNA Chemist RNA Therapeutics

What You Will Do – In this vital role you will focus on advancing programmable mRNA design, synthesis, purification, and characterization strategies, enabling the discovery and development of next‑generation mRNA medicines. You will bring strong expertise in RNA chemistry and nucleic acid therapeutics and work at the interface of molecular design, analytical characterization, and platform innovation, collaborating across multidisciplinary teams to develop robust RNA technologies that improve therapeutic performance, stability, manufacturability, and translational potential.

• Design and implement high‑throughput strategies for modular assembly of mRNA elements to achieve maximal payload expression and programmable cellular performance for therapeutic applications.
• Develop and advance mRNA platform technologies, including chemical modification strategies, capping approaches, and sequence/structure optimization.
• Lead experimental efforts to improve RNA quality, purity, stability, and biological activity.
• Develop and apply purification strategies for mRNA, including experience with FPLC‑based purification methods where applicable.
• Utilize and interpret analytical methods for mRNA characterization, including HPLC, FPLC, LC‑MS, gel electrophoresis, capillary electrophoresis, UV/Vis, and related biochemical and biophysical techniques.
• Evaluate the impact of sequence, structure, chemical modifications, and purification approaches on mRNA performance and develop ability through functional in‑vitro assays.
• Collaborate closely with cross‑functional partners in molecular biology, delivery, formulation, process development, bioanalytics, and translational sciences.
• Clearly document experimental work and communicate findings through internal reports, presentations, patent disclosures, and scientific publications.
• Contribute to the development of scalable and reproducible workflows that support RNA therapeutic platform advancement.

The passionate and dedicated Senior RNA Chemist we seek is a researcher with the following qualifications.

• Doctorate degree (PhD) or PharmD or MD with relevant post‑doctoral experience.
• Masters degree and 3 years of relevant scientific experience.
• Bachelors degree and 5 years of relevant scientific experience.

• PhD + 2 years relevant experience in RNA chemistry, oligonucleotide chemistry, nucleic acid therapeutics, or related discipline.
• Strong background in the design, synthesis, and optimization of RNA molecules, including experience with mRNA and/or circRNA.
• Hands‑on experience with in‑vitro transcription, RNA purification, and analytical characterization.
• Experience in cell culture and functional in‑vitro assays for quantification of RNA expression.
• Experience with FPLC purification and familiarity with chromatography‑based workflows for biomolecule purification.
• Knowledge of modified nucleotides, capping technologies, circularization methods, and structure‑function relationships in RNA systems.
• Understanding of how RNA chemistry and purification impact stability, translation efficiency, immunogenicity, and manufacturability.
• Demonstrated ability to independently design experiments, troubleshoot technical challenges, and drive scientific progress.
• Strong record of collaboration in multidisciplinary drug discovery or platform development environments.
• Excellent written and verbal communication skills, with experience presenting scientific data to cross‑functional teams.
• Track record of innovation as evidenced by publications, patents, or advancement of enabling technologies.

Amgen offers a comprehensive, competitive total rewards plan, including health and welfare plans for staff and eligible dependents, financial plans for retirement or other goals, work/life balance support, career development opportunities, and flexible work models where possible.

Final date to receive applications:
Amgen does not have a deadline; applications will be accepted until a sufficient number of candidates are received or the position is filled.

Sponsorship:
Sponsorship for this role is not guaranteed.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex (including sexual orientation and gender identity), national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation for individuals with disabilities so they can perform essential job functions and receive other employment benefits.