Principal Scientist - Surface Biology Early Validation Lead

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Principal Scientist - Surface Biology Early Validation Lead*
* ** What you will do*
* Let's do this. Let's change the world. We are building a  
** high-throughput surface biology capability
** to enable early validation and characterization of membrane protein targets across Therapeutic Areas. This work focuses on generating high-quality experimental data to deepen understanding of target biology and support downstream therapeutic exploration.

We are seeking an experienced Principal Scientist to lead a team focused on early-stage experimental strategies and assay development to evaluate membrane protein expression, localization, and internalization. In this role, you will guide the development and application of cell-based and quantitative assays, working closely with cross-functional partners to ensure data are robust, scalable, and aligned with discovery needs.

You will operate in a highly collaborative environment, partnering with Therapeutic Area teams and platform functions to deliver biologically relevant insights that support target evaluation.

+ Provide scientific and operational leadership for a team supporting early target validation

+ Lead the design and execution of  
** cell-based and quantitative assays
** to discover and evaluate membrane protein biology

+ Establish robust, scalable workflows to support multiple discovery programs

+ Interpret experimental data and communicate clear, actionable insights to project teams

+ Partner with cross-functional stakeholders across the Discovery Sciences and Advanced Technologies and AI organization, Therapeutic Discovery, and Therapeutic Areas.

+ Collaborate across teams to integrate data and inform target evaluation and prioritization

+ Identify and implement new technologies to enhance assay robustness and throughput

+ Mentor and develop scientists, fostering a culture of rigor, collaboration, and accountability

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Principal Scientist with these qualifications.

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* Basic Qualifications:

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* + Doctorate degree and 3 years of scientific experience OR

+ Master's degree and 7 years of scientific experience OR

+ Bachelor's degree and 9 years of scientific experience OR

+ Associate's degree and 12 years of scientific experience OR

+ High school diploma / GED and 14 years of scientific experience

+ In addition to meeting at least one of the above requirements, you must have a minimum of 3 years of experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation of resources.  Your managerial experience may run concurrently with the required technical experience referenced above

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* Preferred Qualifications:

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* + PhD in Cell Biology, Molecular Biology, or related discipline

+ 5+ years of relevant industry experience, including leadership of scientific projects or teams

+ Expertise in cell-surface biology, membrane protein biology, protein trafficking, receptor biology, or related…