Scientist - LC-MS​/MS Bioanalytical

Join Amgens Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let's do this. Let's change the world. In this vital role you will independently support the design, development, validation, and implementation of robust quantitative LC-MS/MS bioanalytical methods and experiments for small molecules and perform bioanalysis for discovery, GLP preclinical and regulated clinical studies.

The position is lab-based, and additional responsibilities will include critically reviewing and interpreting scientific data and results, report generation, project management, communication of results, data presentations, supporting automation efforts, and keeping current with technology development.

The role will involve multidisciplinary collaborations with scientists across research and development at Amgen and may include contribution to key/critical teams and participation in national scientific meetings. This position is also responsible for providing scientific results that may support the generation of publications, patents or regulatory submissions. Familiarity with peptide and protein quantitation by hybrid LC-MS/MS methodology and affinity capture techniques a plus.

• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times.
• Conduct small molecule bioanalysis of parent and metabolites in non-clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using protein precipitation, SPE, and LLE.
• Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems.
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Author study reports, standard operating procedures, analytical methods, memos, scientific publications, and other regulatory compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.
• Comply with safety guidelines and site-specific procedures which include but are not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures.
• Perform general laboratory housekeeping activities and operational support as needed.

We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.

• Doctorate degree PhD
• PharmD
• MD [and relevant post-doc where applicable]
• Masters degree and 3 years of LC-MS/MS Bioanalytical experience
• Bachelors degree and 5 years of LC-MS/MS Bioanalytical experience

• Prior experience in pharma/biotech strongly desired.
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms.
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, tissues, urine, cerebrospinal fluid) employing diverse sample preparation techniques (e.g., SPE, LLE) to support analysis of small molecules and metabolites by LC-MS/MS.
• Experience with an array of analytical equipment and technologies that can accelerate bioanalysis including automation and/or micro-sampling.
• Prior GLP and GCP experience.
• Prior experience in bioanalytical (regulated) assay execution and method transfer to external contract laboratories.
• Understanding of pharmacokinetic and toxicokinetic principles and analysis.
• Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
• Demonstrated ability to efficiently resolve scientific challenges, prioritize and effectively manage multiple projects.
• Excellent scientific problem-solving…