Senior Scientist - Functional Genomics, -Throughput Screening

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based.

If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist, Functional Genomics, High-Throughput Screening

What You Will Do

Let’s do this. Let’s change the world. In this vital role you will partner closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution; focused on the adaptation and implementation of complex in vitro models to power target discovery and functional genomics efforts. In this essential role for discovery at Amgen, you will be part of a dynamic, cross-functional team to advance target and biological discovery across Amgen’s therapeutic areas.

Key Responsibilities:

• Collaborate with Amgen therapeutic area scientists to leverage appropriate cellular models, gene delivery methods, and perturbation techniques to capture disease-relevant biology.
• Design, optimize, and execute functional arrayed genomic screens in advanced in vitro models (e.g. iPSC-derived cell types, co-cultures, primary cells, organoids, etc.)
• Partner with TD&B and cross-functional team members, including automation colleagues, to accelerate model deployment and reproducibility.
• Identify and implement emerging technologies in high content imaging, cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

Basic Qualifications:

Doctorate degree PhD
OR
PharmD
OR
MD [and relevant post-doc where applicable]
OR
Master’s degree and 3 years of functional genomic screening experience
OR
Bachelor’s degree and 5 years of functional genomic screening experience

Preferred Qualifications:

• Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline
• Functional genomic screening experience; arrayed CRISPR (KO/i/a) and perturbation screening experience preferred; experience in high-throughput or automated screening preferred
• Strong track record in cell engineering and complex in vitro model development
• Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation
• Experience with high-content imaging, automated microscopy, image analysis, feature reduction, and multivariate analysis preferred
• Familiarity with high-throughput screening metrics (e.g. Z’, S/B, MSMR)
• Cell culture experience; iPSC experience and work in complex in vitro cellular models preferred
• Experience with bioinformatics and computational analyses to harness meaningful results from genome-wide datasets
• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
• Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
• Excellent organizational and communication skills, with the ability to drive cross-site…