Sr Scientist

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr Scientist

Let’s do this. Let’schange the world.

We are seeking a motivated Senior Scientist in mass spectrometry–based proteomics to join our talented and collaborative team in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies.

You will contribute to bothpipeline advancement and screening platform innovation by developing and implementing cutting‑edge, high‑throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing,optimizing, and continuouslyenhancing next‑generation screening workflows and analytical platforms.

This role requires hands‑on experienceoperatingand troubleshooting high‑throughput mass spectrometry systems. Your work will play a key role in enabling innovative drug screening strategies, accelerating discovery efforts, and strengthening pipeline support.

• Design,develop, andoptimizehigh‑throughputmass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery
• Execute automated sample preparation and LC‑MS/MS analysis across abroad range of high‑throughput proteomicsassays
• Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data‑driven decision‑making
• Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomicsapproaches
• Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross‑functional teams
• Maintainaccurateand organized documentation of experiments, protocols, and analyses

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist weseekis a scientifically driven, collaborative, and innovative proteomics expert.

Basic Qualifications:

• Doctorate degree (PhD, PharmD, or MD) with relevant experience OR
• Master’s degree and 4 years of directly relatedexperienceOR
• Bachelor’s degree and 6 years of directly related experience

Preferred Qualifications:

• Doctorate degree in proteomics,chemoproteomics, biochemistry, chemistry, ora related discipline
• Strong track recordin developing mass spectrometry–based proteomics assays,operatingadvanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
• Experience with sample preparation miniaturization and automation platforms
• 3+ years of experience in the biotech or pharmaceutical industry
• Demonstrated innovation inassay,method, or platform development
• Strong quantitative and computationalexpertiseinhigh‑dimensionalproteomicsdata analysis
• Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proven track recordof producing reliable and reproducible results.
• Knowledge of targeted protein degradation or E3 ligase…