Associate Scientist, In vivo Pharmacology, Inflammation

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Associate Scientist, In vivo Pharmacology, Inflammation*
* ** What you will do*
* Let's do this. Let's change the world. In this vital role you will work in a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs.

Key Responsibilities:

+ Perform hands-on in vivo work primarily mice, possibly rats in the vivarium daily.

+ Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down.

+ Work side-by-side with Scientists/Senior Scientists to execute and help design experiments.

+ Run concurrent studies, stay organized and detail-oriented to meet study timelines

+ Participate in weekend/evening dosing rotations as needed

+ Support in vitro assays as required

+ Communicate results to immediate team and follow established protocols and safety procedures

+ Work in a flexible team-oriented environment. Weekend and evening work may be required.

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a driven, pro-active, independent, and enthusiastic scientist who wants to contribute to cutting edge science and serve patients in a highly productive team environment with these qualifications.

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* Basic Qualifications:

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* Master's degree and 1 year of Immunology or related experience

OR

Bachelor's degree and 3 years of Immunology or related experience

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* Preferred Qualifications:

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* + M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity.

+ Strong understanding of Immunology and Inflammation biology and principles.

+ Willingness and curiosity to learn and explore new areas of research.

+ Significant experience designing and executing concurrent  _in vivo_  preclinical inflammation and autoimmune disease models.

Experience with colitis (DSS, CD45RB
hi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in Asthma, COPD, HS, PBC a plus.

+ Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymph nodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).

+ Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential.

+ Computer literacy, especially proficiency with Graph Pad Prism, Excel, PowerPoint and Word.

+ Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.

+ Demonstrated track record of independent critical thinking and scientific achievement.

+ Demonstrated experience in pharmacology and  _in vivo_  models of inflammation/Immunology.

** What you can expect of us*
* As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to…