Process Development Sr Scientist

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Process Development Sr Scientist*
* ** What you will do*
* Let's do this. Let's change the world. In this vital role you will define the favorable quality characteristics of the therapies it produces and optimizes state-of-the-art analytical tools to guide that development. The Pivotal PD organizations focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers ("BiTEs"), live oncolytic viruses, and synthetic medicines.

- Identifying and characterizing attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques

- Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography, electrophoresis, and/ or mass spectrometry (LC-MS/MS)

- Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others

- Work in an analytical group equipped with a variety of chromatographic and electrophoretic systems and mass spectrometry platforms

- Communicate (verbal and in written) scientific concepts and results

- Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings

- Work collaboratively with other scientists on multidisciplinary teams

- Work independently in advancing projects and studies within required deadlines

- Actively create or contribute to patent and publications

- Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

*
* Basic Qualifications:

*
* Doctorate degree

OR

Master's degree and 2 years of  
** Scientific
* * experience

OR

Bachelor's degree and 4 years of  
** Scientific
* * experience

*
* Preferred Qualifications:

*
* - Ph.D. in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry, chromatography, electrophoresis, or other analytical technique

- 2 or more year's post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development

- Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications

- Training and experience of operating Thermo Q-Exactive mass spectrometers, Agilent mass spectrometers, and Agilent and Waters HPLCs and UHPLCs and associated data processing software (including empower, chromeleon, biopharmafinder, mass hunter, etc.)

- Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects

- Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP

- Knowledge of programming using R, Python, C++, or machine learning languages

- Experience with automation, robotics, or liquid handlers

- Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staff

** What you can expect from us*
* As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the…