Senior Scientist, Protein Therapeutics – Mammalian Expression & Cell Line Engineering

Career Category Scientific Job  Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will join the Protein Therapeutics organization within Research. This role will lead scientific efforts in mammalian expression and cell line engineering to support the discovery and optimization of large-molecule therapeutics, including antibodies, bispecifics, and next-generation protein modalities.

The successful candidate will be an experienced scientist with deep technical expertise in mammalian expression systems, cell line engineering strategies, and enabling technologies. The individual will contribute to the development and implementation of innovative expression platforms, data‑driven optimization strategies, and automation‑enabled workflows that accelerate biologics discovery.

Serve as a technical expert in mammalian expression and cell line engineering, contributing to technical strategy across protein therapeutic programs.

Develop and implement innovative approaches in mammalian expression and host cell engineering to improve productivity, product quality, and speed.

Evaluate, develop, and implement new technologies, platforms, and automation solutions that enhance the robustness, scalability, and throughput of expression workflows.

Stay current with emerging scientific and technological advances and recommend new approaches that strengthen research capabilities.

Execute wet laboratory experiments to express therapeutic proteins in mammalian cells using both high-throughput bench‑scale and medium-scale shake flask production systems.

Independently solve technically complex problems related to protein expression, post‑translational modification, stability, and develop ability.

Apply data‑driven approaches to optimize expression systems, cell engineering strategies, and experimental workflows.

Partner closely with informatics and automation teams to develop reproducible, scalable, and high‑throughput expression workflows.

Collaborate effectively with cross‑functional teams including protein engineering, molecular biology, analytics, process development, and data sciences to advance discovery programs.

Provide technical guidance and mentorship to junior scientists and contribute to knowledge sharing within the organization.

Represent the mammalian expression and cell engineering function on multidisciplinary project teams and technical working groups.

Maintain awareness of advances in mammalian expression, cell engineering, automation, and data‑enabled biology through scientific…