Scientist, Rare Disease Biology

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Position:
Scientist, Rare Disease Biology*
* ** What you will do*
* Let's do this. Let's change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases by serving as a core member of multidisciplinary disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform portfolio decisions.

This role offers a unique opportunity to establish and leverage advanced human cellular disease models, including iPSC-based systems, to support discovery efforts across rare diseases.

+ Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses.

+ Generate high-quality experimental data to support target identification, validation, and progression of rare disease research programs.

+ Investigate molecular and cellular mechanisms associated with transcriptional dysregulation, protein aggregation, cellular stress responses, and impairment of neurological and neuromuscular processes.

+ Establish scalable experimental platforms that can support multiple rare disease programs.

+ Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.

+ Serve as an active member of disease-focused research pods, collaborating closely with disease biologists, computational scientists, translational researchers, and partner functions.

+ Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.

+ Build and maintain productive relationships with internal and external collaborators, including academic partners, foundations, and scientific experts when appropriate.

+ Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.

+ Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.

+ Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

** What we expect of you*
* We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Scientist with the following qualifications:

** Basic Qualifications*
* + PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline

OR

+ Master's degree and 3 years of scientific research experience

OR

+ Bachelor's degree and 5 years of scientific research experience

** Preferred Qualifications*
* + Experience in neurobiology, genetic disease biology, or related therapeutic areas.

+ Experience studying mechanisms associated with protein aggregation, RNA toxicity, gene silencing, cellular stress responses, or neurological and neuromuscular disease processes.

+ Demonstrated expertise developing, maintaining, and utilizing iPSC-derived cellular models.

+

Experience with neuronal differentiation, glial cell systems, organoid models, or other advanced human cellular systems.

+ Experience working with patient-derived cellular models and genetically engineered cellular systems.

+ Familiarity with CRISPR-based approaches, gene…