Senior Scientist - Automation and HTS – Target Discovery & Biology; TD&B

Career Category Scientific Job Description

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award‑winning culture is collaborative, innovative, and science based.

If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will leverage automation to integrate functional genomics screening, multi-omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution. We are seeking a highly motivated, innovative, and experienced Senior Scientist based in Thousand Oaks to join our team focused on the adaptation and implementation of complex in vitro models to power target discovery and functional genomics efforts.

In this essential role for discovery at Amgen, you will lead our group’s automation efforts and be part of a dynamic, cross‑functional team to advance target and biological discovery across Amgen’s therapeutic areas.

• Develop automation pipelines and strategies to execute functional arrayed genomic screens in high-throughput in advanced in vitro models in collaboration with therapeutic area partners.
• Transfer manual protocol processes in 96w or 384w format to automation platforms.
• Adapt established iPSC differentiation and long‑term cell cultlure protocols to automated instruments to create batches of screen‑ready cells.
• Optimize high content imaging assays and image acquisition parameters, such as those required in Cell Painting experiments, using automated microscopy and image analysis software.
• Identify and implement emerging technologies in robotics, automation, and high content imaging to enhance the sophistication and throughput of discovery platforms.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

• Doctorate degree or Master’s degree and 3 years of functional genomic screening experience or Bachelor’s degree and 5 years of functional genomic screening experience

• Doctorate degree in cell biology, chemical engineering, bioengineering, biomedical engineering, or related discipline
• High throughput screening experience; arrayed CRISPR (KO/i/a) and perturbation screening experience preferred; experience with high content imaging screens preferred
• A high level of comfort working with automation instrumentation;…