Postdoc Fellow - Molecule Discovery

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world.

Responsibilities:

• Develop novel and biopharmaceutical industry leading peptide, protein, antibody and multispecific antibody MS and MS/MS analytical techniques, automation sample handling, digestion, data processing and computational workflows for high order structure determination, that will accelerate Amgen’s therapeutic pipeline.
• This is a 4 year term.

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Postdoc with these qualifications.

Basic Qualifications:

• A doctorate degree (PhD) in biochemistry or analytical chemistry.
• An expert understanding of mass spectrometry, and its application for peptide and protein analytics in a dynamic research environment.
• A good understanding of Python programming.
• A good understanding of molecular dynamics packages.

Preferred Qualifications:

• A doctorate PhD in biochemistry or analytical chemistry, with a focus on mass spectrometry analytical and computational methods.
• A deep understanding of mass spectrometric, intact and sub-unit protein RPLC-MS analyses, bottom-up RPLC-MS/MS approaches, other protein structural analytical methods and techniques for post translational modifications (PTMs) and high order structure determination and inference will be advantageous.
• Experience with HDX-MS, FPOP, X-linking or other covalent labelling techniques will be advantageous.
• A good understanding of protein digestion methods, sample handling, MS and LC automation and application is highly desired.
• Experience with Agilent LC-ToF/Q-ToF MS, Thermo Orbitrap QExactive and Fusion Tribrid MS and Waters Q-ToF instruments are highly desired.
• Experience handling and analyzing large-scale MS, MS(MS) and/or proteomics datasets using statistical and machine learning techniques is desirable
• A good working knowledge and experience with scientific computing libraries such as Num Py, pandas, Sci Py, or scikit-learn will be advantageous.
• A working understanding of molecular dynamics, such as Molecular Operating Environment (MOE) and/or Schrodinger and Alpha Fold is preferred.
• Familiarity with running software in cloud computing environments is highly preferred.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is $82,000.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field…