Scientist - Erythroid Biology

** Join Amgen's Mission of Serving Patients*
* At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas
-Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

** Scientist - Erythroid Biology*
* ** What you will do*
* Let's do this. Let's change the world. In this vital role you will. A Scientist at Amgen is responsible for designing and conducting experiments, analyzing results, and interpreting data. They prepare technical reports, summaries, and protocols and present study results at team meetings. They also assist in maintaining lab equipment, troubleshooting issues, and ensuring safety protocols are adhered to.

** Responsibilities:*
* Design and execute  _in vitro_  and  _ex vivo_  assays to evaluate siRNA delivery and function

Develop human primary cell-based systems

Support target validation and mechanism-of-action studies for siRNA therapeutics

Collaborate with Delivery/chemistry teams, Translational and biomarker teams

Establish and optimize Flow cytometry panels, qPCR / RNA-based readouts

Contribute to IND-enabling studies and data packages

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* Basic Qualifications:

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* Doctorate degree

Master's degree and 2 years scientific experience

OR

Bachelor's degree and 4 years scientific experience

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* Preferred Qualifications:

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* Experience with siRNA / RNA therapeutics (delivery or functional assays), Erythroid biology and hematopoiesis.

Strong background in Flow cytometry (multi-color), Cell-based functional assays

Familiarity with gene expression (qPCR, RNA assays), target engagement assays Experience working in cross-functional drug discovery teams

Knowledge on Hemoglobinopathies, conjugated delivery systems, CRISPR or gene editing is a plus

** What you can expect of us*
* As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

+ A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

+ A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

+ Stock-based long-term incentives

+ Award-winning time-off plans

+ Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

** Apply now and make a lasting impact with the Amgen team.*
* ***
* In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

** Final date to receive applications*
* ** External/Internal postings:*
* Amgen does not have an Final date to receive applications for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

** Internal only posting (or Pre-):*
* Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

** Sponsorship*
* Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing…