Senior Principal Scientist, Bioanalytical

Job Description

Job Description

Senior Research Scientist
- Onsite, Lenexa, KS
- Full-Time;
Flow Cytometry

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

We are excited to be seeking a new Senior Principal Scientist at ICON in Lenexa, Kansas (KS). The Senior Principal Scientist will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with proven method development and Spectral Flow Cytometry experience.

The Senior Principal Scientist is responsible for method development and validation for testing preclinical and clinical specimens using flow cytometry, and ligand-binding analytical methods. In addition, you will oversee transfer robust flow cytometry methods for further for bioanalytical testing.

• Flow cytometry
  • Experience with Spectral Flow
  • Panel design
  • Gating strategy design
  • Usage of cytometry software (e.g. FACSDiva, FCS express)
• Ligand binding assays
  • ELISA, ECLIA
  • PK, PD, and immunogenicity
  • Usage of relevant software (e.g. Soft Max Pro, Watson)

• Designs and executes experiments for method development
• Develops new scientific approaches to method development and communicates these to the global science team
• Mentors junior scientists and advises operation on developed methods
• Reviews and approves data of other scientists
• Communicates with team members and management regarding project status, purpose, scheduling, problems, etc.
• Lead communication with clients regarding project status.

• Maintain knowledge and skill in all techniques where you perform your work.
• Provide scientific input to management and BD about new technology investments and lines of service.
• Own discussions regarding scientific results with sponsors, together with project manager
• Promotes ICON utilizing scientific skills through scientific communication such as external publication of posters and journal articles.
• Perform R&D projects
• Training of technicians on technical aspects
• Mentor and train staff on scientific topics

• Takes initiative in process development and SOP/WI writing
• Legible, logical and reproducible documentation of all experimentation
• Has a thorough understanding and complies with GLP and other appropriate regulations
• Develops rugged and economical assays
• Performs data review of other scientist’s work

• Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
• Assay troubleshooting
• May perform and document maintenance, trouble-shooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.

• Read, write and speak fluent English
• Spectral flow cytometry experience
• 10-15 years of relevant laboratory experience
• MS or PhD with applicable research in a relevant scientific field, preferred
  
  Presenter/Publisher in Regulated relevant field, preferred

#LI-KM3

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

• Competitive base salary and performance related incentives
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable
• Retirement and pension plans
• Life assurance and disability cover