Senior Scientist Structural Biology

We are currently recruiting for Senior Scientist (Structural Biology). This is a permanent position based at our site in Alderley Park.

Job Title: Senior Scientist (Structural Biology)

Job Type: Permanent

Working Hours: Monday – Friday, 40 hours per week

Location: Alderley Park, Macclesfield, SK10 4TG

Responsible for establishing and executing Structural Biology work plans. Accountable for delivery of Structural Biology projects within early drug discovery, across multiple modalities and therapeutic areas, within their area of expertise.

• Design and execute agreed work plans for early drug discovery projects, in alignment with project goals, budgets, and timelines.
• Support multiple concurrent projects and, when required, direct internal resources to achieve agreed objectives.
• Review and interpret experimental results to ensure data quality and alignment with project specifications.
• Accountable, in partnership with project counterparts, for experimental design, documentation review, and client presentations, including thorough data analysis prior to release to internal or external customers.
• Propose experimental designs and novel approaches to identify and advance optimal project strategies, in addition to planning and executing agreed deliverables.
• Represent the company at scientific and/or business conferences, as appropriate.
• Present and publish peer‑reviewed scientific work, contributing to personal development and enhancing Evotec’s scientific reputation.
• Ensure accurate, efficient, and timely data recording and reporting for all laboratory procedures.
• Oversee routine maintenance and calibration of laboratory instruments to ensure accurate and reliable performance.
• Adhere to laboratory safety protocols and proactively contribute to improving safety practices in line with current recommendations.

• Strong technical expertise in protein biochemistry, structural biology, and/or biophysics, with a proven ability to design and deliver results across multiple target families within agreed timelines, budgets, and quality standards.
• Demonstrated experience leading cryo‑EM and/or X‑ray crystallography projects, from sample preparation through structure refinement, analysis, and delivery.
• Hands‑on experience operating cryo‑EM instrumentation (e.g., Titan Krios, Glacios) and/or strong understanding of synchrotron data collection strategies.
• Proficiency in processing and analyzing structural data using relevant software packages, such as RELION, cryo
  
  SPARC, Phenix, Global Phasing, and/or CCP
  4.
• Proven ability to collaborate effectively with computational, biophysical, and medicinal chemistry teams to inform and guide structure‑based drug design.
• Experience preparing and executing project work plans and building trusted partnerships with internal and external stakeholders.
• Track record of high‑quality scientific problem‑solving and cross‑functional collaboration, delivering impactful results.
• Demonstrated research experience with peer‑reviewed publications in a relevant scientific field.

Ideally, a PhD or equivalent experience in structural biology and biophysics, with some experience in an industrial setting. Alternatively, a relevant first degree combined with several additional years of experience in drug discovery.

• Pension on completion (not subject to) of your 3‑month probationary period. Contributions 5% for employees (salary sacrifice) and 5% for the employer. The employee can opt to increase their contribution, and the employer will match the increase up to a maximum of 7.5%.
• 25 days holiday plus bank holidays and additional length of service days awarded on the anniversary, up to a maximum of 30 days.
• Private health insurance with BUPA for the employee and their partner/family under the company scheme.
• Wellbeing support 24/7 and counselling services.
• Permanent health insurance provides 75% of the base salary after the qualifying period.
• Private dental cover, on completion (not subject to) of your 3‑month probationary period.
• Eligibility to participate in the Company Bonus Scheme. This is a discretionary benefit.
• Career progression within the company, excellent training and support and continuing professional development opportunities.
• Cycle‑to‑work scheme.
• Refer a friend scheme, team and annual events, recognition awards and many more.

• The company pays for secure onsite parking.
• Restaurant, Café, and Gastro pub.
• Gym and workout studio, running, walking, and cycling routes.
• Good public transport links with the shuttle bus service.

FR :
Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.

ENG :
In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.