Post Doctoral Research Fellow- Wu Lab

Postdoctoral Research Fellow - Wu Lab

The Wu laboratory at the Masonic Medical Research Institute (MMRI) is seeking a highly motivated postdoctoral fellow to delve into multiple exciting projects to understand transcriptional and post-transcriptional regulation in heart disease. Our laboratory combines mouse genetics with cutting-edge multi-omics approaches, including bulk RNA-seq, single-cell RNA-seq, single-cell ATAC-seq, spatial transcriptomics, ChIP-seq, and CLIP-seq, to uncover the complex gene regulatory networks governed by transcription factors and RNA-binding proteins during cardiac development and disease.

Through these studies, we aim to define the molecular mechanisms underlying congenital and acquired heart diseases, including left ventricular noncompaction (LVNC), and to identify new therapeutic strategies for improving cardiovascular health.

About the PI

Dr. Tongbin Wu earned his B.S. and Ph.D. degrees from Wuhan University, where he trained under the mentorship of Dr. Xiang-Dong Fu, a world-renowned scientist in RNA biology. He then joined the University of California San Diego (UCSD) for postdoctoral training in the laboratory of Dr. Ju Chen, a distinguished investigator in cardiovascular research. In 2023, Dr. Wu joined the Masonic Medical Research Institute (MMRI) as an Assistant Professor and established his independent research program.

His work focuses on uncovering the molecular mechanisms that govern heart development and disease, with a particular emphasis on RNA regulation and gene regulatory networks. Dr. Wu has made significant contributions to the field, publishing research articles in leading journals including Circulation, Circulation Research, Proceedings of the National Academy of Sciences (PNAS), and American Journal of Physiology-Heart and Circulatory Physiology.

Selected recent publications:

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We provide:

• An opportunity to present your work at national/international conferences.
• Support for publication of high and medium impact journal articles. We are also strong advocates of preprints.
• A supportive environment that keeps your short and long-term career goals in mind. Your success is our success!
• Clear expectations provided in structured project management.
• A closely-knit, exceptionally equipped research institute with a wide variety of research interests and expertise.
• An appreciation for work/life balance; sometimes the best ideas come when not in the lab!
• A highly competitive compensation and benefits packages
• A position in the very affordable Mohawk Valley of Upstate New York: an ideal region for those interested in myriad outdoor adventures including those in the Adirondack State Park, the largest park in the contiguous United States.

Requirements

Preferred Qualifications

• A recent or pending Ph.D. in the cardiovascular research or related fields.
• Proficient in molecular and cell biology techniques.
• Experience in small animal handling techniques.
• Experience in generating and analyzing next-generation sequencing (NGS) datasets.
• Demonstrated productivity in the form of first author publications and presentations
• Excitement to tackle difficult scientific questions in areas that will involve significant development of technical and analytical workflows
• Scientific creativity to identify novel approaches to answer our research questions
• A hard working and collegial attitude
• A desire to work in an informal, highly collaborative, and scientifically rigorous laboratory environment.

Experience with any of the following:

• Experimental execution, performance, and data collection
• Research Protocol
• Scientific Terminology
• Flexible – ability to change directions as needed for the benefit of laboratory.
• Performance Excellence – high responsibility, pleasant to work with, provides timely and accurate information.
• Organized – manages time effectively, keeps tasks appropriately prioritized.
• Critical Thinking – ability to think through issues and identify appropriate options.
• Work Ethic – motivated, diligent, industrious, and…