Summer Intern, CMC Process Development

The Position

The CMC Process Development Summer Intern will support the evaluation and implementation of new technologies for oligonucleotide and antibody conjugation, supporting Arrowhead's Antibody-Oligonucleotide Conjugate (AOC) and oligo-bioconjugate programs. The intern will contribute to process understanding and optimization efforts aimed at improving manufacturing throughput and crude conjugate impurity profiles. This role provides exposure to cutting-edge bioconjugation technologies, analytical techniques, and collaborative process development in an industrial setting.

This is an 11-week Summer Internship Program paying $21.00 per hour and requires full-time, onsite work five days per week at the designated location.

Responsibilities

* Work closely with CMC Process Development team members to execute experiments using flow chemistry systems and tangential flow filtration (TFF).

* Support process development efforts for AOC programs and oligo-bioconjugates formed off resin.

* Perform analytical characterization of oligonucleotide and antibody intermediates and conjugates using standard HPLC and mass spectrometry (MS).

* Characterize and identify process- and product-related impurities.

* Maintain clear, accurate, and timely documentation of experimental procedures and results.

* Discuss experimental outcomes with team members and contribute to data interpretation.

* Manage time effectively to meet project milestones and internship goals.

Requirements

* Currently enrolled student at an accredited university or college, sophomore level or higher focused in Chemistry, Biochemistry, or a related field.

* Completion of at least one organic chemistry course.

* Interest in learning and applying a variety of laboratory instrumentation and techniques.

* Excellent verbal and written communication skills, including comfort presenting in group settings.

* Strong problem-solving and organizational skills.

* Proficiency in Microsoft Office applications.

* Ability to lift up to 40 lbs.

* Willingness and ability to spend 75% of the workday in walking around the facility and 25% at a desk

* Ability to work in a laboratory environment for extended periods, including wearing required personal protective equipment (PPE).

Preferred

* Prior exposure to HPLC techniques.

* Previous academic or industry research experience.

* Experience working with macromolecules such as oligonucleotides or proteins.