Associate Scientist III, CMC Process Development

The Position

The Associate Scientist III works in the Chemistry, Manufacturing, and Controls Group focusing on oligonucleotide synthesis development. This is an ideal position for an individual with an organic chemistry background who has an interest in projects related to novel technology in synthesis and purification of oligonucleotides and bioconjugates.

Responsibilities

* Work independently or with senior scientists to develop new synthetic approaches to desired compounds while keeping an eye toward large-scale synthesis

* Perform solid-phase synthesis and purification of oligonucleotide drug candidates

* Mentor others on internal protocols, practices and processes

* Analyze small-molecule and macromolecular targets using standard methods

* Recognize unusual circumstances, identify root cause(s) to problems, and begins providing recommendations to new approaches, techniques and/or practices

* Maintain a well-documented laboratory notebook

* Cerate an action plan with project deliverables with high-level guidance

* Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings

* Independently coordinate delivery of materials both internally and externally

Requirements

* MS in Chemistry or related field (minimum 2 years of relevant laboratory experience) or BS in Chemistry with 5+ years of experience

* Experience with synthetic organic chemistry

* Excellent verbal and written communication skills

* Strong problem-solving skills

* Eagerness to learn new techniques

Preferred

* Experience working with small molecule or large molecule synthetic targets either in an academic or industrial setting

* Basic familiarity with GLP/GMP regulations

* Experience with small-molecule or macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.)