Senior Clinical Trial Manager

About Neurocentria

Neurocentria is a clinical-stage neuroscience company developing magnesium L‑threonate (MgT) as a precision intervention for cognitive health and neurological disorders. Our lead compound uniquely elevates brain magnesium by crossing the blood–brain barrier — a mechanism of action originating from 20 years of research. Two completed human trials have demonstrated significant cognitive effects, and our current clinical program represents a pivotal scientific and commercial milestone for the company.

Neurocentria is a clinical-stage neuroscience company developing magnesium L‑threonate (MgT) as a precision intervention for cognitive health and neurological disorders. Our lead compound uniquely elevates brain magnesium by crossing the blood–brain barrier — a mechanism of action originating from 20 years of research. Two completed human trials have demonstrated significant cognitive effects, and our current clinical program represents a pivotal scientific and commercial milestone for the company.

We are looking for a Senior Clinical Trial Manager to serve as the primary operational lead for two concurrent decentralized Phase 2 clinical trials in neurology and cognitive health. Both studies are fully decentralized — no in-person clinic visits — with all assessments conducted remotely or through local laboratory networks.

This is a senior individual contributor role within a lean internal team. You will work directly with the Principal Investigator and Head of Clinical Operations, owning day-to-day CRO performance, vendor relationships, budgets, timelines, and regulatory compliance from study startup through database lock.

• Serve as the primary sponsor-side point of contact for the full-service DCT CRO, monitoring performance weekly against contractual deliverables across both trials
• Identify and escalation operational risks proactively — enrollment trends, screen failure rates, dropout signals, data quality issues, and timeline slippage — before they become milestone failures
• Lead study startup activities including CRO RFP coordination, proposal evaluation, and contract review; confirm all regulatory gates are cleared before enrollment opens
• Maintain Trial Master File completeness and audit readiness; track and triage protocol deviations and SAE reporting timelines
• Manage trial budgets and CRO invoicing across both studies; evaluate change order requests and prepare recommendations for approval
• Support IND amendments, IRB submissions, and regulatory authority interactions as directed by the Principal Investigator

• Bachelor’s degree in life sciences, clinical research, nursing, or a related field; advanced degree preferred (MS, MPH, PharmD)
• Minimum 8 years of clinical trial operations experience in the pharmaceutical or biotechnology industry
• Demonstrated experience as primary operational lead on at least one Phase 2 or later IND-quality clinical trial, from startup through database lock
• Minimum 3 years of direct CRO oversight in a sponsor-side role, including vendor selection, performance management, and change order negotiation
• Experience with decentralized clinical trials (DCT) or hybrid trial models, including remote subject management, electronic consent, and digital endpoint or ePRO platforms
• Strong working knowledge of ICH GCP guidelines (E6 R2/R3), 21 CFR 312, and eTMF standards
• Proficiency with EDC systems (REDCap, Medidata Rave, or equivalent)

• CNS, neurology, or cognitive health therapeutic area experience strongly preferred
• Experience with blood‑based biomarker logistics in a clinical trial setting
• Familiarity with digital cognitive assessment platforms or tablet‑administered endpoint…