Director, US Commercial Enablement

Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X, Linked In and Facebook.

The Director, US Commercial Enablement drives strategic commercial enablement initiatives and builds foundational tools, processes, and capabilities to support business growth and launch readiness. The Director establishes and optimizes field enablement infrastructure, including incentive compensation, CRM platforms, and business intelligence tools, while ensuring alignment across cross‑functional stakeholders. This role enhances field effectiveness, builds scalable processes, and promotes operational excellence with a patient‑first mindset.

This position is based in Waltham, MA.

• Leads planning, design, and administration of incentive compensation and bonus programs across commercial, medical, and patient services teams
• Develops plan design models, manages payouts, and delivers monthly and quarterly reporting
• Maintains plan documentation, tracking systems, and performance monitoring processes
• Conducts regular performance reviews with stakeholders to optimize program effectiveness
• Partners with field teams to build account planning tools
• Leads recognition programs, including Circle of Excellence and associated planning

• Serves as commercial business owner for CRM platforms (e.g., Veeva), translating field needs into system enhancements
• Partners with IT and stakeholders to implement and optimize CRM and data solutions
• Owns business intelligence reporting tools and ensures data accuracy through quality control processes
• Supports reporting platforms across market access and patient services
• Optimizes field enablement tools and materials to improve productivity and effectiveness

• Designs and implements fleet program aligned with business needs and industry benchmarks
• Maintains and updates fleet policies in collaboration with Compliance, HR, Finance, and Field Leadership
• Builds scalable processes to support field teams and commercial operations

• Leads coordination of national, regional, and headquarters meetings in partnership with Marketing and Commercial teams
• Drives cross‑functional planning across Sales, Marketing, Market Access, Advanced Analytics, Patient Services, Finance, and IT
• Ensures alignment and readiness to support commercial launch and execution
• Strengthens collaboration and communication across teams

• Bachelor’s degree; advanced degree preferred
• 12+ years of experience in biotech, pharmaceutical, or life sciences industry, including field sales, sales leadership, field operations, or consulting experience supporting commercial organizations
• Demonstrated experience supporting or leading launch readiness, ideally in rare disease, neuromuscular, neurodegenerative, or neurodevelopmental therapies
• Strong leadership and project management experience, including managing vendors and scaling commercial infrastructure
• Strategic mindset with ability to execute and deliver results
• Experience with commercial technology platforms and data environments (e.g., CRM, BI tools, Snowflake, Boomi, SP/SIP, HUB data)
• Strong analytical and problem‑solving skills
• Excellent written and verbal communication skills, including ability to present to senior leadership
• Demonstrated ability to collaborate effectively across cross‑functional stakeholders

MA Pay Range: $188,000—$235,000 USD. The pay range reflects the base pay range Dyne reasonably expects to…