Director, Global Supply Chain Excellence & Digital Enablement Lead

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction‑associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Leads supply chain operational excellence and digital enablement to standardize best practices and improve execution performance across global teams. Owns a continuous improvement pipeline with disciplined intake, prioritization, delivery, and benefits tracking. Partners with IT / Analytics to simplify processes, automate workflows, and improve execution visibility through consistent metrics and reporting. Builds standard work, SOPs, and performance routines that reduce variability and improve plan‑to‑execution reliability.

Ensures improvements are sustained through training, coaching, and controls.

• Standardize SOPs, templates, and performance routines, embed standard work and controls across teams
• Run CI pipeline (intake, prioritization, delivery, benefits tracking) and ensure sustainment mechanisms are in place
• Produce deliverables such as SOP / templates library, CI backlog, benefits tracker, and sustainment / control plans

• Partner with IT / Analytics to automate workflows and improve dashboards / visibility aligned to operational needs
• Lead training, adoption tracking, and sustainment actions to embed new capabilities into daily routines
• Produce deliverables such as dashboard requirements, adoption metrics, training materials, and revised SOPs / standard work

• Establish KPI routines and escalation paths, ensure metrics drive action and consistent follow‑up
• Build capability in structured problem solving and continuous improvement practices
• Produce deliverables such as KPI packs, tier‑cadence agendas, and problem‑solving toolkits

• BS+ (Supply Chain, Engineering, Business, or related)
• 12–15 years in supply chain excellence / CI roles scaling standards across teams / sites
• Demonstrated track record delivering measurable improvements and sustaining adoption

• Lean / Six Sigma certification (or equivalent) with applied results
• Familiarity with ERP / APS / WMS / TMS environments and process digitization
• Experience in pharmaceutical / biotech or other regulated operations (preferred)

• Operational excellence, standard work / SOP governance, and KPI routines, benefits tracking and sustainment controls
• Digital enablement partnering (workflow automation, dashboards, reporting), adoption monitoring and corrective action
• Change management (impact assessment, stakeholder mapping, communications, training / SOP readiness, adoption measurement)
• Structured problem solving, root cause analysis, and continuous improvement pipeline management
• Cross‑functional leadership, escalation, and executive‑ready performance / risk communication

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower…