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Senior​/Contracts Manager

Job in Waltham, Middlesex County, Massachusetts, 02254, USA
Listing for: Crescent Biopharma
Full Time position
Listed on 2026-07-26
Job specializations:
  • Business
    Regulatory Compliance Specialist
Salary/Wage Range or Industry Benchmark: 140000 - 180000 USD Yearly USD 140000.00 180000.00 YEAR
Job Description & How to Apply Below

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors.

For more information, visit  and follow the Company on Linked In and X.

We areseekinga

Senior/Contracts Managertoleadday-to-daycontractintake,drafting,negotiation support, execution, and contract operations across the company. This role is for a business-focused contracts professional, not a practicing attorney. You will partner closely with cross-functional leads and drive a high-volume portfolio of research, clinical, and corporate agreements with a focus on speed, precision, and business-oriented risk management.

The right candidate is highly organized, practical, responsive, and comfortable managing a high volume of agreements in a fast-moving biotechnology environment. You should be able to spot issues, drive process, keep stakeholders aligned, and escalate legal or business risks appropriately.
This role is based in Waltham, MA and you must have experience in biotech.

Responsibilities
  • Drive the full contract lifecycle by drafting and reviewing a high volume of core biotech agreements, includingCDAs,Master Service Agreements (MSAs),complex

    Statements of

    Work(SOWs),Consulting Agreements, vendor and supply agreements, Clinical Trial Agreements (CTAs) and clinical and research-related service agreements.
  • Manageroutineandmid-levelnegotiationsdirectlywithcounterpartiesandescalatemateriallegal, regulatory, IP, privacy, insurance, compliance, and liability issues when needed.
  • Providestrategiccontractualguidancetocross-functional teams,actingasafirstlineofdefenseto identify and mitigate potential operational, regulatory, and business risks within agreements.
  • Maintainandimprovecontracttemplates,clause libraries,negotiation guidelines,andinternalplaybooks.
  • Optimize contract infrastructure by leading management of a Contract Lifecycle Management (CLM) system(Link Squares) totrackcontractstatus,keyterms,renewal dates,termination rights,notice deadlines,payment obligations, and other critical milestones.
  • Supportcontractgovernance,includingsignatureauthority,version control,records management,and repository hygiene.
  • Support audit,diligence,financing,andbusinessdevelopmentrequestsbyorganizingandsummarizing agreement data.
  • Identifybottlenecksandrecommendprocessimprovementsthatreducecycletimewithoutweakeningcontrols.
  • PartnerwithkeyinternalstakeholderstoensurecontractexecutionisalignedwithCBIO’sstrategic goals, project timelines, and budgetary requirements.
  • Partner with the finance department to continuously improve the contract/PO process and lifecycle.
  • Upholdrigorouscompliancestandardsbyensuringallcontractsmeetapplicablelaws,industry regulations, and clinical standards, including FDA, GCP, and GDPR.
Education & Experience
  • Bachelor’s degree is required. 5+ years (7+ for Senior level) ofprofessionalexperienceincontractmanagement,specificallywithinthelifesciencesor biotech sectors.
  • Experience negotiating CTAs in the US and rest of world (ROW) is required.
  • Demonstratedexperiencemanagingahighvolumeofagreementsacrossmultiplebusinessfunctions with strong attention to detail, organization, and follow-through.
  • Strongdraftingandredliningskills.
  • Abilitytoidentifylegalandbusinessriskissuesandescalateappropriately.
  • Experienceinafast-paced,high-growthstartupenvironment.
  • Highproficiencywithmodernlegaltechnology,includingCLMplatforms(we use Link Squares), Docu Sign, AI-assisted contract review and drafting tools, and the Microsoft Office Suite. Link Squares experience is not required but is highly desired.
  • FamiliaritywithIP-relatedcontractprovisions,including licensing termsand publication rights.
What We Offer
  • Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment
  • Co…
Position Requirements
10+ Years work experience
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