Associate Director, U.S. Tax Operations & Reporting

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH.

Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.

To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Reporting to the Executive Director, Tax, the Associate Director, U.S. Tax Operations & Reporting will be accountable for Madrigal’s U.S. tax operations and global tax reporting infrastructure, including ASC 740 tax reporting, U.S. compliance, financial statement and tax authority audit readiness, SOX-aligned controls, tax technology enablement, and external advisor management. This hands-on role requires a tax professional who can independently drive work from planning through execution, deliver audit-ready work product, bring clear recommendations to senior leadership, and translate complex tax matters into practical business guidance for Finance and business partners.
** Key Outcomes for Success
*** Deliver accurate, timely, audit-ready quarterly and annual tax reporting under ASC 740, including the tax provision, UTPs, effective tax rate, Form 10-K/10-Q disclosures, and documentation supporting key judgments.
* Convert tax risks and technical analyses into concise recommendations, options, and decision points for senior leadership and business partners.
* Build capacity and operational leverage within the Tax function by leading external advisors and cross-functional work streams with clear priorities, accountability, and continuous improvement.
* Establish a scalable, well-governed tax operating model that strengthens controls, improves efficiency, and supports the Company's continued growth.
* Advance the Tax function's technology and data capabilities by leveraging automation, system enhancements, and scalable digital solutions to improve efficiency, reporting accuracy, and business insights.
** Key Responsibilities
** Tax Provision and Financial Statements
* Own the quarterly and annual ASC 740 income tax provision process, including effective tax rate analysis, deferred tax inventory, valuation allowance assessment, uncertain tax positions, and tax-related balance sheet accounts.
* Direct the tax close calendar, deliverables, work papers, review process, tax footnotes, disclosures, quarterly reviews, and annual audit support to deliver timely, accurate public company reporting.
* Own technical tax accounting conclusions for complex and non-routine matters, directing preparation of supporting memoranda and presenting recommendations to the Executive Director, Tax and Finance leadership.
* Drive alignment with Corporate Accounting, International Finance, FP&A, Treasury, and external auditors on forecasting, cash tax projections, reporting requirements, and key tax accounting judgments.

U.S. Tax Compliance, Operations & Audit Support
* Oversee U.S. federal, state, local, Puerto Rico, and…