Senior Manager, Clinical Programming

Our commitment to people with neuromuscular diseases

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities.

The Senior Manager, Clinical Programming is responsible for overseeing and managing programming activities related to clinical trial data. The person in this role will ensure high-quality management of clinical trial data through effective programming strategies, driving best practices in programming, and ensuring that all clinical data is captured, processed, and reported to meet regulatory expectations and internal standards. This role collaborates closely with cross‑functional teams, including clinical operations, biostatistics, and data management, to facilitate the successful execution of clinical trials.

The person in this role leverages their expertise in programming and data management to create robust analytical databases, support regulatory submissions, and contribute to clinical study reports that showcase the efficacy and safety of our therapies.

This role leads Clinical Programming projects and initiatives by navigating complex problems in support of Electronic Data Capture (EDC), external data handling, and data visualization. This role performs programming tasks from study start‑up to close‑out according to the Standard Operating Procedures (SOPs), International Council for Harmonisation– Good Clinical Practice (ICH‑GCP), and all applicable regulatory requirements.

This role is based in Waltham, MA.

• Oversee assigned day‑to‑day clinical programming activities, timelines, and deliverables for assigned projects
• Collaborate with clinical operations, biostatistics, and data management teams to develop project timelines and ensure alignment of programming deliverables with clinical study objectives
• Monitor project progress, identify potential issues, and implement solutions to mitigate risks
• Provide technical and business expertise in support of data deliverables
• Ensure compliance within internal policies, SOPs, and Work Instructions as well as external regulatory requirements related to clinical data management and programming
• Conduct quality checks and audits of programming deliverables to guarantee accuracy and integrity
• Identify opportunities for process improvements within clinical programming and data management practices and implement changes to enhance efficiency and quality
• Effectively interact with vendors
• Anticipate internal business challenges and successfully drive towards the best solution for the organization
• Participate ineffective planning and execution of programming tasks
• Ensure timeliness and quality of data report deliverables in collaboration with Clinical Data Management team members and cross‑functional colleagues
• Enable consistent programming approaches, standards adoption, and best practices
• Work closely with stakeholders to support data analysis and reporting needs
• Participate in initiatives around process development, standardization, and technology
• Contribute to selection and use of complex programming solutions to enhance clinical data collection and reporting
• Provide oversight of programming tasks performed by third‑party vendors and data management Contract Research Organizations (CROs) as assigned
• Stay current with emerging technologies and methodologies relevant to the role

• 6+ years of experience in clinical programming with a focus on clinical data management and analysis within the pharma/biotech industry
• Bachelor’s degree in life science or related discipline required, advanced degree preferred
• Has in-depth knowledge of clinical database design, data standards, and data output…