Executive Director​/Vice President, Project Management

About Us

We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH
103), is purposefully engineered with extended half‑life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self‑administered subcutaneous injections. Our second clinical candidate, DNTH
212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease‑modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self‑administered subcutaneous injections. To learn more, please visit  and follow us on Linked In.

The Executive Director or Vice President of Project Management will provide hands‑on leadership to support integrated project planning across the full lifecycle of drug development, from early clinical development through regulatory approval and commercialization. You will be responsible for creating, maintaining, and driving detailed, cross‑functional project plans that align clinical, regulatory, CMC, nonclinical, quality, and commercial activities to ensure the timely and successful delivery of clinical programs.

You will serve as a central operational integrator, working closely with cross‑functional teams to identify efficiencies, manage interdependencies, and ensure clear communication and execution at the program level. This position includes mentorship and day‑to‑day guidance of junior project managers while remaining focused on detailed execution.

This is an exciting opportunity to join a growing clinical‑stage organization as we continue to expand our pipeline. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients' lives. We are open to you working remotely.

• Create, own, and maintain detailed integrated project plans and experience with multiple communication tools (e.g. Gantt charts, Dashboards, timeline views etc.) for one or more clinical programs across all stages of development.
• Define milestones, deliverables, dependencies and critical path activities in collaboration with functional teams.
• Ensure project plans are realistic, up to date, and reflect cross‑functional assumptions and constraints.

• Partner closely with cross‑functional teams, including Clinical Operations, Clinical Development, Regulatory Affairs, CMC, Nonclinical, Quality, Biostatistics, Medical Affairs, and Commercial.
• Facilitate project team meetings, working sessions and planning discussions to drive alignment and execution.
• Identify and manage cross‑functional interdependencies, handoffs and timing risks, ensuring visibility across teams.
• Proactively identify opportunities for operational efficiencies and improved coordination.

• Work with teams to identify project risks, gaps, and tradeoffs; document and track mitigation plans.
• Support scenario planning to assess schedule impacts and operational options.
• Clearly communicate risks, issues, and mitigation strategies to relevant stakeholders in a timely manner.
• Ensure transparency of issues, risks, and mitigation plans to senior leadership.

• Apply and continuously improve project management tools, templates, and best practices appropriate to the program stage and complexity.
• Ensure consistency, accountability, and execution rigor across programs.
• Mentor and support junior project managers, providing guidance on planning, dependency management, and cross‑functional coordination.
• Contribute to building scalable and practical project management capabilities within the organization.

• Act as a trusted partner to the executive team, providing clear, concise, and data‑driven project insights.
• Prepare high‑quality project updates and materials for program stakeholders and Senior…