Senior Clinical Trial Associate

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera isleveragingits proprietary switch-control kinase inhibitor platform and deepexpertisein kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’splatform in clinical studies, QINLOCK® (ripretinib) is Deciphera’sswitch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.

ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatictenosynovialgiant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.

The spirit of collaboration that has brought medications to life continues to guide how weoperate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together.

Deciphera offers competitive compensation, including equity-based compensation,and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, lifeinsuranceand a flexible spending account for either health care and/or dependent care.

We are seeking a detail-oriented and proactive Senior Clinical Trial Associate (Sr. CTA) to support the successful execution of clinical studies within Clinical Operations. In this role, you will partner closely with study leads and cross-functional teams to manage key components of clinical trials, ensuring delivery against timelines, budgets, and quality standards.

This is an excellent opportunity for a clinical operations professional who thrives in a fast-paced environment and is eager to contribute to high-impact clinical programs.

• Coordinate cross-functional study team meetings, including agenda development and meeting minutes
• Support clinical site start-up activities and ongoing site management efforts
• Assist in managing external vendors and ensure alignment with study expectations
• Participate in, and occasionally present at, Investigator Meetings

• Maintain and track study documentation to ensure compliance with internal standards and regulatory requirements
• Support Trial Master File (TMF) management, including document filing and quality control
• Assist with development, editing, and distribution of key study documents (e.g., informed consent forms, manuals)
• Maintain study trackers, tools, and systems to support study execution

• Analyze clinical systems and processes to identify risks to data quality and integrity
• Provide input into protocol feasibility and identify opportunities to optimize study delivery
• Develop and manage study timelines, proactively identifying risks and escalating issues as needed
• Support clinical trial budgeting activities and cost tracking
• Track regulatory documents (e.g., 1572s) and collaborate with Regulatory on submissions such as INDs
• Support sample management and contribute to review of core study documents…