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Senior Manager, US Medical Affairs

Job in Waltham, Middlesex County, Massachusetts, 02254, USA
Listing for: BioSpace
Full Time position
Listed on 2026-09-14
Job specializations:
  • Healthcare
    Medical Science Liaison, Medical Education
Salary/Wage Range or Industry Benchmark: 165000 - 190000 USD Yearly USD 165000.00 190000.00 YEAR
Job Description & How to Apply Below

Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X, Linked In and Facebook.

Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X, Linked In and Facebook.

Role Summary

The Senior Manager, US Medical Affairs supports execution of Dyne’s US Medical Affairs strategy for the Duchenne Muscular Dystrophy (DMD) program. This role contributes to critical launch readiness activities and supports the planning and delivery of US Medical initiatives, including KOL engagement, congress execution, medical education efforts, and cross-functional coordination. The Senior Manager operates as both a scientific and operational contributor, helping prepare the US Medical organization for anticipated DMD program needs.

This role partners closely with Medical Science Liaisons (MSLs), Global Medical Affairs, and cross-functional stakeholders to ensure medical activities are high-quality, compliant, and impactful. This role is based in Waltham, MA.

Primary Responsibilities Include Medical Strategy Execution & Launch Readiness
  • Supports execution of US Medical Affairs tactical plans for the DMD program
  • Assists in implementing scientific platform materials, congress planning, and medical education initiatives
  • Contributes to cross-functional launch readiness activities to ensure alignment with program milestones
  • Supports development and deployment of DMD-focused scientific materials, disease state education resources, and field medical tools
Field Medical & KOL Engagement
  • Partners with the US MSL team to support KOL identification, engagement planning, insight gathering, and field metric tracking
  • Translates field insights into actionable recommendations for Medical Affairs and cross-functional teams
  • Tracks and monitors field activity and engagement effectiveness
Scientific Materials & Medical Review
  • Contributes to development of scientific materials, field tools, and educational content
  • Provides Medical review for promotional materials through the Promotional Review Committee (PRC)
  • Maintains deep and current scientific knowledge in DMD and Dyne’s therapeutic platform
Congress & External Engagements
  • Supports planning and execution of medical congresses, including onsite activities aligned to DMD milestones
  • Coordinates logistics and execution of US advisory boards and expert engagements
Cross-Functional Collaboration & Compliance
  • Partners with Patient Advocacy, Market Access, and Commercial teams to support aligned medical activities
  • Ensures all activities comply with US regulatory, legal, and compliance standards
  • Models Dyne’s core values through…
Position Requirements
10+ Years work experience
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