Manager​/Senior Manager, IT Desktop Support

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical‑state pipeline includes its lead program, a PD‑1 x VEGF bispecific antibody, as well as novel antibody‑drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors.

For more information, visit  and follow the Company on Linked In and X.

We are seeking a hands‑on, strategic IT Manager to build, manage, and scale our IT infrastructure during a period of rapid growth  will help oversee corporate IT systems, cybersecurity, data governance, laboratory IT support, and vendor management. To be successful in this role, you have experience in biotech, life sciences, or regulated environments and understand the unique IT needs of laboratory operations, data integrity, and compliance frameworks (e.g., GxP, HIPAA, FDA 21 CFR Part 11).

Please note, this position is onsite in Waltham, MA.

$0 - $0 a year

• Lead hardware lifecycle planning (laptops, networking equipment and any other IT/Facilities related hardware)
• Ensure high availability, performance, and disaster recovery readiness
• Plan for office expansion, lab expansion, and hybrid/remote workforce needs
• Oversee identity and access management (IAM), MFA, endpoint protection, and monitoring
• Ensure compliance with GxP environments, FDA 21 CFR Part 11, SOC 2 readiness
• Support risk assessments and security audits
• Develop incident response and business continuity plans
• Manage MSPs[KD1], cloud vendors, and software contracts
• Negotiate licensing and SaaS agreements
• Support annual IT budget projections
• Evaluate and implement new technologies to improve productivity
• Oversee management of Microsoft Office 365, collaboration tools, HRIS, ERP systems
• Enhance current onboarding/offboarding processes
• Provide escalation support for helpdesk issues
• Implement scalable IT policies and documentation
• Assess when to hire internal IT support as the company grows

• B.S. and 5+ years of progressive IT experience in life sciences, biotech or pharma
• Strong knowledge of Cloud platforms (Azure, AWS, or GCP), M365 administration, cybersecurity frameworks and endpoint management, networking fundamentals
• Experience with compliance frameworks (GxP, HIPAA, 21 CFR Part 11, or SOC
  2)
• Proven ability to manage vendors and IT budgets
• Excellent communication skills across technical and non‑technical teams

The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short‑ and long‑term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)).

This position is eligible to participate in the Company’s long‑term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits:
Vacation – Unlimited PTO;
Sick time – 10 days per calendar year;
Holiday pay, including two Company shut downs;
Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA;
Military Leave. Additional information can be found -

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.