Director, US Commercial Enablement

Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X, Linked In and Facebook.

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X, Linked In and Facebook.

The Director, US Commercial Enablement drives strategic commercial enablement initiatives and builds foundational tools, processes, and capabilities to support business growth and launch readiness. The Director establishes and optimizes field enablement infrastructure, including incentive compensation, CRM platforms, and business intelligence tools, while ensuring alignment across cross-functional stakeholders. This role enhances field effectiveness, builds scalable processes, and promotes operational excellence with a patient-first mindset.

This position is based in Waltham, MA

• Leads planning, design, and administration of incentive compensation and bonus programs across commercial, medical, and patient services teams
• Develops plan design models, manages payouts, and delivers monthly and quarterly reporting
• Maintains plan documentation, tracking systems, and performance monitoring processes
• Conducts regular performance reviews with stakeholders to optimize program effectiveness
• Partners with field teams to build account planning tools
• Leads recognition programs, including Circle of Excellence and associated planning

• Serves as commercial business owner for CRM platforms (e.g., Veeva), translating field needs into system enhancements
• Partners with IT and stakeholders to implement and optimize CRM and data solutions
• Owns business intelligence reporting tools and ensures data accuracy through quality control processes
• Supports reporting platforms across market access and patient services
• Optimizes field enablement tools and materials to improve productivity and effectiveness

• Designs and implements fleet program aligned with business needs and industry benchmarks
• Maintains and updates fleet policies in collaboration with Compliance, HR, Finance, and Field Leadership
• Builds scalable processes to support field teams and commercial operations

• Leads coordination of national, regional, and headquarters meetings in partnership with Marketing and Commercial teams
• Drives cross-functional planning across Sales, Marketing, Market Access, Advanced Analytics, Patient Services, Finance, and IT
• Ensures alignment and readiness to support commercial launch and execution
• Strengthens…