Executive Director, Strategic Projects

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.

To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Executive Director, Strategic Projects is a strategic partner and advisor to the Commercial Leadership Team, responsible for driving alignment, execution, and operational excellence across commercial functions including Marketing, Sales, Thought Leader Liaisons, Market Access, Patient Access, Commercial Strategy & Operations, Government Affairs and Meetings & Events. This role ensures clarity and momentum for key priorities and innovation opportunities, facilitates cross-functional collaboration, and leads high-impact strategic initiatives that support business objectives and accelerate growth.

This is an office-based role, either in Conshohocken, PA or Waltham, MA. Reports into Chief Commercial Officer and collaborates closely with Marketing, Sales, Thought Leader Liaisons, Market Access, Patient Access, Commercial Strategy & Operations, Government Affairs and Meetings & Events.

• Lead or support high-priority commercial projects, innovation initiatives, or transformation programs.
• Translate CLT decisions into actionable plans and monitor progress against goals.
• Prepare briefs, analyses, and recommendations as needed to support decision-making.

• Liaise between Commercial and cross-functional partners (Finance, Medical, HR, Legal, IT, etc.) to ensure alignment, escalate as needed and/or remove barriers to execution.
• Ensure cross-functional collaboration to support timely execution of key priorities and projects.

• Support the execution of key organizational processes (e.g., governance implementation, brand planning processes, quarterly tactical execution reviews, financial planning processes etc.).
• Partner with internal teams to identify inefficiencies and implement scalable operational improvements.

• Lead development of high-impact materials and presentations for executive forums, Board reports, and leadership communications.
• Organize and facilitate key commercial meetings, ensuring agendas are focused and decisions are documented and actionable.

• Define project scope, objectives, and deliverables.
• Develop detailed project plans, timelines, and budgets.
• Ensure adequate allocation of resources to successfully deliver outcomes.
• Assemble and lead cross-functional project teams.
• Assign tasks, set priorities, and monitor team progress.
• Foster a collaborative and motivated team environment.
• Provide regular updates on project status, milestones, and risks.
• Manage stakeholder expectations and address concerns proactively.
• Monitor project progress using KPIs and performance metrics.
• Prepare and present comprehensive project reports to CLT.
• Evaluate project outcomes to identify lessons learned.
• Recommend improvements to processes for future projects.

• Bachelor’s degree in business, life sciences, marketing, or related field (MBA…