Regional Business Director, (Midwest Region), Immunology

Regional Business Director, Immunology

Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas' lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them.

We believe that obexelimab's unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton's Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas' earlier stage programs include ZB021, a clinical-stage, potentially best-in-class, oral, IL-17AA/AF inhibitor;

ZB022, a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor; and ZB014, a preclinical half-life extended anti-CD-19 and FcγRIIb monoclonal antibody.

We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation !

Position Summary:

The Regional Business Director (RBD), Immunology, is a critical commercial leadership role responsible for driving sales performance, strategic execution, and customer engagement across a defined geographic region. This includes the design and implementation of business plans based upon strategic business analysis. This leader will manage, coach, and develop a team of high-performing Account Managers (AMs) to ensure exceptional performance in a competitive rare disease, specialty market.

The RBD will collaborate cross-functionally to optimize field strategy, enhance customer experience, and support successful launches within the immunology portfolio. This position reports to the SVP, US Commercial Engagement and Access.

Key Responsibilities:

Regional Leadership & Team Management

• Hire, lead, develop, and inspire a team of Account Managers to achieve and exceed regional sales goals.
• Establish a high-performance culture focused on accountability, integrity, strategic execution, and professional development.
• Develop and implement performance plans to support AM skill growth, capability building, and succession planning.
• Conduct regular field rides and coaching sessions to model best practices and reinforce customer-centric engagement.
• Ensure compliance with all company policies, legal requirements, and industry standards in all field activities

Strategic Planning & Execution

• Translate national brand strategy into actionable regional business plans tailored to local markets, customer needs, and competitive dynamics.
• Leverage market data, customer insights, and analytics to identify opportunities and challenges and adjust strategies accordingly.
• Oversee pull-through of brand initiatives, launch plans, and disease-area priorities across the region.
• Partner with Marketing, Market Access, Medical Affairs and other internal stakeholders to ensure aligned compliant execution.

Customer & Market Engagement

• Establish and maintain relationships with key customers, including HCPs, administrators, and influential institutions across immunology.
• Support AMs in developing deeper customer insights and effective territory plans.
• Ensure customer needs and marketplace dynamics are communicated to inform strategy, planning, and resource allocation.

Cross-Functional Collaboration

• Collabora…