Senior Program Manager, Program Leadership and Management

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK® (ripretinib) is Deciphera’s switch‑control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.

ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.

The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together.

Deciphera offers competitive compensation, including equity‑based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

We are seeking a dynamic Sr. Program Manager, Program Leadership & Management, to provide leadership, strategic direction and program management to our Development and Commercial Program Teams. In partnership with the Program Lead, the Sr Program Manager will drive development and deliver results for programs in early to late phase clinical development and/or lifecycle management programs. The successful candidate should possess and demonstrate a firm understanding of drug development, be comfortable with ambiguity, and have strong communication skills, enabling effective communication within program teams and throughout the organization.

This role is highly cross‑functional and will involve collaboration with internal and potentially external partners. In partnership with the Program Lead, the Sr. Program Manager is charged with leading daily program management activities, including the development and execution of the program’s Integrated Development Strategy. He/she/they is expected to have an understanding of the overall program strategy and critical path activities, including risks and potential mitigation plans.

• Strategic partner to the Program Lead, enabling development and ensuring execution of the Integrated Development Strategy – 50%
  • In partnership with the Program Lead, drives the development and execution of strategic, integrated development plans through effective leadership of Program Teams
  • Provides clear direction on product development requirements to meet the expectations of external customers and business stakeholders
  • Monitors program progress and related KPIs, identifies gaps and risks and makes strategic recommendations
  • Supports the execution and continuous re‑assessment of development strategy in support of the overarching corporate strategy
• Ensures the effective and consistent operation of high‑functioning program teams – 50%
  • Facilitates program team meetings to ensure productive and efficient discussion
  • Ensures clear and timely communication of program strategy and progress to relevant stakeholders
  • Orchestrates the integration of sub‑teams to support the effectors of Program Teams

• Bachelor’s with 8+ years of R&D and/or drug development project management experience
• Strong…