Scientist I​/II, In Vitro Pharmacology

The Company

We are Alloy Therapeutics— a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK;
Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day.

We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!

Alloy’s In Vitro Pharmacology team collaborates with drug discovery partners to conduct in vitro studies on therapeutic candidates across diverse modalities. Our team delivers comprehensive functional screening and characterization of biologics to support discovery and selection of lead candidates. Primary modalities are monoclonal, multispecific, and TCR-mimic antibodies, but also include cell therapies and genetic medicines. As Alloy Tx enters its next phase of growth, we are expanding our capabilities to include mechanistic studies that enhance preclinical development and further advance our translational research efforts.

We are seeking a highly motivated Scientist for in vitro screening and pre-clinical development to join our dynamic and fast-paced team. In this role, you will support the execution of in vitro functional cell-based assays to evaluate the potency, mechanism of action, and pharmacological properties of biologic therapeutics. This role requires exceptional organizational skills, a commitment to scientific excellence, and the ability to adapt to a dynamic environment.

You will report to the Associate Director, In Vitro Pharmacology and will work collaboratively in a matrixed environment to drive biologics discovery while supporting rapid decision-making in a fast-moving biotech setting.

• Execute:
  Support in vitro functional characterization of drug candidate molecules.
• Develop:
  Bring a proactive mindset to optimize workflows for more efficient and effective data generation.
• Deliver:
  Support screening campaigns to meet experimental timelines for monoclonal and multispecific antibodies, as well as TCR-mimic antibodies.
• Collaborate:
  Work closely across multi-disciplinary teams in biologics discovery programs spanning all Alloy sites. Engage with an inclusive and collaborative work environment.
• Communicate:
  Clearly convey scientific concepts, experimental results, and interpretations to internal and external stakeholders.

• Develop and optimize cell-based activity assays for primary and/or engineered human immune cells (T cells, NK cells, macrophages, etc).
• Process human leukopaks, isolate and characterize human PBMCs.
• Expansion and analysis of primary or genetically modified primary T cells and other immune…