Associate Scientist​/Principal Associate Scientist, Protein Analytics

The Company

We are Alloy Therapeutics— a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre‑competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non‑exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100 % of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK;
Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on‑site and full‑time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship‑By‑Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face‑to‑face. Of course, as a lab‑based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day.

We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!

Alloy's Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across an array of discovery and development activities, including assay development, detailed biophysical characterization, high‑throughput screening, and quality control of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities.

We are seeking a highly motivated Associate Scientist or Principal Associate Scientist to conduct in‑vitro screening and analytical characterization as part of our dynamic, fast‑paced biotech team. In this role, you will design & execute Liquid Chromatography Mass‑Spectrometry (LC‑MS) experiments, purity assessments, recombinant protein‑binding screens, and develop ability evaluations. You will work collaboratively in a matrixed environment to advance biologics discovery and support rapid, data‑driven decision‑making.

This role will report to the Head of Protein Analytics and offers significant autonomy, with ownership of multiple stakeholders, projects, and tasks in a dynamic start‑up environment, while maintaining the pace and standards of Alloy.

• Execute:
  Perform LC‑MS based characterization of antibodies, purity assessments, protein binding, and develop ability characterization.
• Develop:
  Optimize experimental workflows for more efficient and effective data generation.
• Deliver:
  Support discovery and development projects for monoclonal and multispecific antibodies, as well as TCR‑mimic antibodies.
• Collaborate:
  Work closely across multi‑disciplinary teams in biologics discovery programs spanning all Alloy sites. Engage with an inclusive and collaborative work environment.
• Communicate:
  Clearly convey scientific concepts, experimental results, and interpretations to internal and external stakeholders.

• Design and conduct LC‑MS based experiments.
• Develop new methods and optimize existing workflows.
• Perform purity assessments (SEC‑HPLC, CE‑SDS, etc.).
• Maintain analytical instrumentation and ensure best practices are followed.
• Support protein binding assays using BLI (Octet) and SPRi (Carterra LSA).
• Support develop ability assessments utilizing an array of in‑vitro methods.
• Present experimental data and findings during team meetings.
• Ensure timely and successful execution of project…