Principal Research Associate​/Associate Scientist, Molecular Assembly

Position Summary:

TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. The ideal candidate should have relevant experience in cloning techniques and enjoy a fast-paced, collaborative, and vibrant culture.

A team player with a sense of urgency will thrive in this role.

Responsibilities:

* Collaborate with other scientists to design and build various constructs and vectors in support of target/TCR discovery efforts.

* Assemble large libraries of peptides, TCRs, etc. using specialized cloning protocols.

* Perform medium- to high-throughput cloning experiments to support discovery efforts in target identification and validation.

* Analyze and interpret cloning and screening data (e.g., sequencing, functional assays) to guide construct design and optimization.

* Troubleshoot complex cloning and library construction challenges and propose scalable solutions.

* Lead group efforts towards technology development and improvement.

* Implement and optimize high-throughput workflows, including automation where applicable.

* Train co-workers on molecular cloning techniques.

* Maintain accurate and well-documented experimental records (e.g., ELN) to ensure data integrity and reproducibility.

Requirements:

* PhD with 0-2+ years of industry experience;
Masters degree with 5-7+ years of relevant lab experience, preferably in the biopharmaceutical or biotechnology industry.

* Hands-on experience in a variety of molecular cloning techniques, including Gibson Assembly, Golden Gate Assembly, Gateway recombination, etc.; experience constructing large-scale libraries is desirable.

* Highly organized with very strong attention to detail.

* Demonstrated ability to manage multiple projects and meet deadlines in a fast-paced environment.

* Ability to work both independently and collaboratively and adapt quickly to changing priorities.

* Scientific creativity, critical thinking, and problem-solving skills.

* Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.

* Familiarity with sequence analysis tools, NGS, and basic bioinformatics workflows preferred.

* Knowledge of immunology concepts, especially TCR biology and antigen recognition, is preferred.