Senior Scientist Bioscience
Job in
Waltham, Middlesex County, Massachusetts, 02254, USA
Listed on 2026-06-30
Listing for:
The Fountain Group
Full Time
position Listed on 2026-06-30
Job specializations:
-
Research/Development
Research Scientist, Immunology Research, Biotech Research, Drug Discovery
Job Description & How to Apply Below
Title: Scientist/Senior Scientist Bioscience
Location: Waltham, MA – will be moving to Cambridge later this year
Duration: 6 months (With Possible Extension/Hire)
Pay range: $50–61 / hour on W2
Job DescriptionSeeking a hands‑on Senior Scientist to support cell therapy programs focused on autoimmune and immunology indications. This role will lead in vitro target validation and functional characterization of engineered cell therapies, with a strong emphasis on CAR‑T research, complex immunological assays, and data‑driven program advancement. The position requires independent experimental execution, cross‑functional collaboration, and scientific leadership within a discovery research environment.
- Design, execute, and optimize in vitro assays to evaluate engineered cell therapies and therapeutic targets
- Perform target validation studies using primary human cells and functional co‑culture systems
- Characterize CAR‑T cell activity through cytotoxicity, proliferation, phenotyping, and cytokine analysis assays
- Develop mechanism‑of‑action studies to support cell therapy discovery programs
- Analyze and interpret experimental data to guide program decisions and target selection
- Utilize flow cytometry and multiplex immunological assays to assess cellular function and immune responses
- Maintain high-quality experimental documentation and data records
- Present scientific findings, risks, and recommendations to project teams and leadership
- Support study planning, milestone execution, and cross‑functional research initiatives
- Contribute to translational research activities advancing cell therapy candidates toward development
- PhD in Immunology, Cell Biology, Molecular Biology, or related discipline with 0–5 years of relevant experience; OR
- MS or BS in a related scientific field with significant industry experience in cell therapy, immunology, or translational research
- CAR‑T cell therapy research
- Primary human cell culture
- Functional cell‑based assays
- Cytotoxicity assays
- Multi‑color and spectral flow cytometry
- Flow Jo data analysis
- T‑cell transduction and engineered cell products
- T‑cell proliferation and phenotyping assays
- Multiplex cytokine analysis
- Mechanism‑of‑action studies
- Immunophenotyping
- Assay development and optimization
- Experimental design and statistical data interpretation
- Graph Pad Prism
- Cell therapy target validation
- Discovery‑stage immunology research
- Gene editing technologies
- CAR target discovery
- MSD cytokine quantification platforms
- Intracellular cytokine staining
- RT‑qPCR
- Autoimmune disease research (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease)
- In vivo autoimmune disease models
- Murine pharmacology studies
- Pharmacodynamic and efficacy endpoint analysis
- Biotech or pharmaceutical industry experience in cell therapy discovery
Position Requirements
10+ Years
work experience
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