Associate Scientist, In Vitro Pharmacology

Overview

Company:
Alloy Therapeutics — a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Alloy democratizes access to pre-competitive tools, technologies, services, and company creation capabilities to accelerate drug discovery and development of therapeutic biologics. Alloy enables affordable, non-exclusive access across academia, small and medium biotech, and biopharma. Alloy reinvests 100% of revenue in innovation and access to innovation.

MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK;
Basel, Switzerland; and Athens, GA. We value accountability, deliberate trust, and open communication, and strive to maintain a nimble, startup culture while collaborating across the global organization. This is an on-site and full-time position in Waltham, MA. We emphasize a mentorship-by-apprenticeship ethos and aim for in-person collaboration when needed. As a lab-based operation, our cells and animals operate daily. We value colleagues with varying flexibility and encourage mutual respect within the team.

Alloy’s In Vitro Pharmacology team collaborates with drug discovery partners to conduct in vitro studies on therapeutic candidates across diverse modalities. The team delivers functional screening and characterization of biologics to support lead discovery. Primary modalities include monoclonal, multispecific, and TCR-mimic antibodies, with additional work on cell therapies and genetic medicines. Alloy Tx is expanding capabilities to include mechanistic studies to enhance preclinical development.

We are seeking a highly motivated Associate Scientist for in vitro screening and pre-clinical development to join our dynamic, fast-paced team. You will support execution of in vitro functional cell-based assays to evaluate potency, mechanism of action, and pharmacological properties of biologic therapeutics. The role requires exceptional organizational skills, scientific excellence, and adaptability. You will report to the Associate Director, In Vitro Pharmacology and work collaboratively in a matrixed environment to drive biologics discovery and support rapid decision-making.

How You’ll Drive Impact

• Execute: Perform in vitro characterization and functional assays to screen drug candidate molecules.
• Develop: Optimize experimental workflows for more efficient data generation.
• Deliver: Support screening campaigns to meet timelines for monoclonal, multispecific, and TCR-mimic antibodies.
• Collaborate: Work across multi-disciplinary teams in biologics discovery programs across Alloy sites. Foster an inclusive and collaborative environment.
• Communicate: Clearly convey scientific concepts, experimental results, and interpretations to internal and external stakeholders.

Principal Responsibilities

• Design, optimize and execute cell-based assays (e.g., cell binding and blocking assays, functional assays) using immortalized cell lines, primary cells, and other disease-relevant systems.
• Maintain cell lines in culture using aseptic techniques.
• Process human leukopaks, isolate and characterize human PBMCs.
• Support day-to-day lab and experimental workflows.
• Collaborate across divisional or departmental teams and with external partners to drive projects forward and obtain test materials and reagents.
• Present experimental data and findings during team and departmental meetings.
• Ensure timely and successful execution of project activities aligned with plans and priorities.
• Maintain detailed and accurate laboratory records in compliance with industry standards.
• Maintain laboratory organization and ensure safety protocol compliance.

• B.S. and M.S. in Cell or Molecular Biology (or related field) with 2–4 years of relevant industry experience.
• Strong understanding of immunology and extensive hands-on laboratory experience.
• Significant cell culture and flow cytometry experience.
• Experience with antibody-based therapeutics preferred.
• Proficient in fundamental cell and molecular biology assays (ELISA/MSD, AlphaLISA, etc.).
• Ability to troubleshoot, maintain, and optimize instrumentation.
• Direct experience with immune…