Senior Scientist Bioscience

The Fountain Group is currently seeking a Scientist/Senior Scientist Bioscience for a prominent client of ours. This position is located at Waltham,MA. Details for the position are as follows:

Title:

Scientist/Senior Scientist Bioscience

Location:

Waltham,MA - will be moving to Cambridge later on this year
Duration: 6 months (With Possible Extension/Hire)
Pay range: : $50-61/ Hour on W2

Job Description

Seeking a hands-on Senior Scientist to support cell therapy programs focused on autoimmune and immunology indications. This role will lead in vitro target validation and functional characterization of engineered cell therapies, with a strong emphasis on CAR-T research, complex immunological assays, and data-driven program advancement. The position requires independent experimental execution, cross-functional collaboration, and scientific leadership within a discovery research environment.

• Design, execute, and optimize in vitro assays to evaluate engineered cell therapies and therapeutic targets
• Perform target validation studies using primary human cells and functional co-culture systems
• Characterize CAR-T cell activity through cytotoxicity, proliferation, phenotyping, and cytokine analysis assays
• Develop mechanism-of-action studies to support cell therapy discovery programs
• Analyze and interpret experimental data to guide program decisions and target selection
• Utilize flow cytometry and multiplex immunological assays to assess cellular function and immune responses
• Maintain high-quality experimental documentation and data records
• Present scientific findings, risks, and recommendations to project teams and leadership
• Support study planning, milestone execution, and cross-functional research initiatives
• Contribute to translational research activities advancing cell therapy candidates toward development

Education

• PhD in Immunology, Cell Biology, Molecular Biology, or related discipline with 0–5 years of relevant experience; OR
• MS or BS in a related scientific field with significant industry experience in cell therapy, immunology, or translational research

Required Skills

• CAR-T cell therapy research
• Primary human cell culture
• Functional cell-based assays
• Cytotoxicity assays
• Multi-color and spectral flow cytometry
• Flow Jo data analysis
• T-cell transduction and engineered cell products
• T-cell proliferation and phenotyping assays
• Multiplex cytokine analysis
• Mechanism-of-action studies
• Immunophenotyping
• Assay development and optimization
• Experimental design and statistical data interpretation
• Graph Pad Prism
• Cell therapy target validation
• Discovery-stage immunology research

Preferred Skills

• Gene editing technologies
• CAR target discovery
• MSD cytokine quantification platforms
• Intracellular cytokine staining
• RT-qPCR
• Autoimmune disease research (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease)
• In vivo autoimmune disease models
• Murine pharmacology studies
• Pharmacodynamic and efficacy endpoint analysis
• Biotech or pharmaceutical industry experience in cell therapy discovery

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