Research Associate - Oligonucleotide Chemistry

Research Associate Position

The Company We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN. Alloy has evolved from a startup into a global biotechnology infrastructure company operating 11 divisions across 5 research sites in 4 countries on 3 continents.

Our model - Integrated Independence - combines centralized capabilities with entrepreneurial operating divisions. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture. At Alloy, we have an ethos of "Mentorship-By-Apprenticeship" in all of our positions.

We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days a year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility.

We are all one team!

The Role We are seeking a highly motivated Research Associate to join our Nucleic Acid Chemistry team. The successful candidate will contribute to the synthesis, purification, formulation, and analytical characterization of modified oligonucleotides supporting discovery and early development programs. Working in a fast-paced startup environment, the successful candidate will contribute to established workflows while developing expertise in oligonucleotide synthesis technologies, purification methods, and analytical characterization.

This role offers significant opportunities for technical growth and increasing scientific responsibility.

• Perform synthesis, deprotection, purification, formulation, and characterization of modified oligonucleotides using automated synthesizers and established protocols.
• Operate analytical instrumentation including HPLC, LC-MS, UV-Vis spectrophotometers, gel electrophoresis, and AKTA purification systems.
• Analyze experimental data to determine identity, purity, concentration, yield, and other critical quality attributes.
• Assist in troubleshooting and optimizing synthesis, purification, and analytical methods.
• Prepare oligonucleotide materials for in vitro and in vivo studies.
• Maintain accurate experimental records, laboratory inventory, and equipment.
• Follow laboratory safety practices and contribute to SOP development and continuous process improvement.
• Collaborate with scientists across chemistry, biology, DMPK, and analytical sciences to support research objectives

• BS in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related discipline with 1-3 years of relevant industry or academic research experience, or MS in a related discipline with 0–2 years of relevant experience.
• Hands-on laboratory experience with oligonucleotide synthesis, purification, analytical characterization, or related nucleic acid chemistry.
• Familiarity with automated oligonucleotide synthesizers (e.g., Mermade or equivalent).
• Basic understanding of phosphoramidite oligonucleotide synthesis chemistry.
• Strong laboratory, troubleshooting, organizational, and documentation skills.
• Excellent…