Cell Therapy Scientist

The Fountain Group is currently seeking a Senior Cell Therapy Scientist for a prominent client of ours. This position is located in Waltham, MA and will later move to Cambridge this year.

Title: Scientist/Senior Scientist Bioscience

Location: Waltham, MA - will be moving to Cambridge later this year

Duration: 6 months (with possible extension/hire)

Pay range: $50-61 per Hour on W2

• PhD level scientist or someone with 10+ years is a must
• CAR T-cell experience / cell therapy experience (at least 2-3+ years of experience with CAR T-cell experience)
• Discovery group experience / not in process development
• Need someone with biological assays experience
• In vitro side is the main focus of this position
• In vivo experience is a plus but not required
• Mouse experience
• Publication in cell therapy would be a big indicator they are a decent fit
• Degree in cell therapy or immunology is a plus
• Someone who can jump into lab immediately - execute these assays
• Cytotoxicity assays
• Onsite interviews highly preferred
• 100% lab based position

Seeking a hands-on Senior Scientist to support cell therapy programs focused on autoimmune and immunology indications. This role will lead in vitro target validation and functional characterization of engineered cell therapies, with a strong emphasis on CAR‑T research, complex immunological assays, and data-driven program advancement. The position requires independent experimental execution, cross-functional collaboration, and scientific leadership within a discovery research environment.

• Design, execute, and optimize in vitro assays to evaluate engineered cell therapies and therapeutic targets
• Perform target validation studies using primary human cells and functional co-culture systems
• Characterize CAR‑T cell activity through cytotoxicity, proliferation, phenotyping, and cytokine analysis assays
• Develop mechanism-of-action studies to support cell therapy discovery programs
• Analyze and interpret experimental data to guide program decisions and target selection
• Utilize flow cytometry and multiplex immunological assays to assess cellular function and immune responses
• Maintain high-quality experimental documentation and data records
• Present scientific findings, risks, and recommendations to project teams and leadership
• Support study planning, milestone execution, and cross-functional research initiatives
• Contribute to translational research activities advancing cell therapy candidates toward development

• PhD in Immunology, Cell Biology, Molecular Biology, or related discipline with 0–5 years of relevant experience; OR
• MS or BS in a related scientific field with significant industry experience in cell therapy, immunology, or translational research

• CAR‑T cell therapy research
• Primary human cell culture
• Functional cell-based assays
• Cytotoxicity assays
• Multi-color and spectral flow cytometry
• Flow Jo data analysis
• T‑cell transduction and engineered cell products
• T‑cell proliferation and phenotyping assays
• Multiplex cytokine analysis
• Mechanism-of-action studies
• Immunophenotyping
• Assay development and optimization
• Experimental design and statistical data interpretation
• Graph Pad Prism
• Cell therapy target validation
• Discovery-stage immunology research

• Gene editing technologies
• CAR target discovery
• MSD cytokine quantification platforms
• Intracellular cytokine staining
• RT‑qPCR
• Autoimmune disease research (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease)
• In vivo autoimmune disease models
• Murine pharmacology studies
• Pharmacodynamic and efficacy endpoint analysis
• Biotech or pharmaceutical industry experience in cell therapy discovery